ArticleNature communications2021
A molecular switch in sulfur metabolism to reduce arsenic and enrich selenium in rice grain.
Article in Nature communications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 113 citations in OpenAlex.
- Sulfur metabolism-dependent retrograde signaling for oxidative stress acclimation.Journal of experimental botany · 2026Review
- Sulfate starvation response modules connect sulfur metabolism to photorespiration and photosynthesis.The Plant journal : for cell and molecular biology · 2026Article
- Functional Genomics of Sulfur Metabolism in Rice: Insights From Transgenic and MicroRNA-Based Strategies.Plant direct · 2026Review
- Fruit consumption as a gut health improving strategy to lower arsenic exposure risk from rice consumption.Eco-Environment & Health · 2026Article
- Deciphering the mechanism of selenium-induced resistance to TR4 in bananas via proteomic profiling.BMC plant biology · 2026Article
- Integrated Transcriptomic and Metabolomic Analyses Reveal Adaptive Mechanisms ofPlants (Basel, Switzerland) · 2026Article
- The chloroplast cysteine synthase complex in guard cells is critical for stress-induced stomatal closure.Plant physiology · 2026Article
- Novel roles of sulfur metabolism in stress-controlled stomata aperture regulation.The New phytologist · 2026Review
- Toward an understanding of selenium accumulation in rice: a preliminary transcriptomic inquiry of selenium fertilizer forms.BMC biotechnology · 2026Article
- Engineering delivery platforms for CRISPR-Cas and their applications in healthcare, agriculture and beyond.Nanoscale advances · 2026Review
- The plastid cysteine synthase complex regulates ABA biosynthesis and stomatal closure in Arabidopsis.Nature communications · 2025Article
- PromoterEco-Environment & Health · 2025Article
- Revealing Genomic Traits and Evolutionary Insights of Oryza officinalis from Southern China Through Genome Assembly and Transcriptome Analysis.Rice (New York, N.Y.) · 2025Article
- Recent Advances in Transcriptome Analysis Within the Realm of Low Arsenic Rice Breeding.Plants (Basel, Switzerland) · 2025Review
- Catalysts for sulfur: understanding the intricacies of enzymes orchestrating plant sulfur anabolism.Planta · 2024Review
- Genome-Wide Identification of theInternational journal of molecular sciences · 2024Article
- Biological self-protection inspired engineering of nanomaterials to construct a robust bio-nano system for environmental applications.Science advances · 2024Article
- Adaptive modifications in plant sulfur metabolism over evolutionary time.Journal of experimental botany · 2024Review
- Metabolomic profiling reveals key factors and associated pathways regulating the differential behavior of rice (Oryza sativa L.) genotypes exposed to geogenic arsenic.Environmental monitoring and assessment · 2024Article
- Functional nutritional rice: current progresses and future prospects.Frontiers in plant science · 2024Review
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Rice grains typically contain high levels of toxic arsenic but low levels of the essential micronutrient selenium. Anthropogenic arsenic contamination of paddy soils exacerbates arsenic toxicity in rice crops resulting in substantial yield losses. Here, we report the identification of the gain-of-function arsenite tolerant 1 (astol1) mutant of rice that benefits from enhanced sulfur and selenium assimilation, arsenic tolerance, and decreased arsenic accumulation in grains. The astol1 mutation promotes the physical interaction of the chloroplast-localized O-acetylserine (thiol) lyase protein with its interaction partner serine-acetyltransferase in the cysteine synthase complex. Activation of the serine-acetyltransferase in this complex promotes the uptake of sulfate and selenium and enhances the production of cysteine, glutathione, and phytochelatins, resulting in increased tolerance and decreased translocation of arsenic to grains. Our findings uncover the pivotal sensing-function of the cysteine synthase complex in plastids for optimizing stress resilience and grain quality by regulating a fundamental macronutrient assimilation pathway.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.