ArticleNature communications2021
Immunogenicity and protective efficacy of inactivated SARS-CoV-2 vaccine candidate, BBV152 in rhesus macaques.
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Article in Nature communications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers, 1 of them a synthesis that pooled it.
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57citing papers in PubMed, 1 pooled it
5.3field-weighted citation impact, top 3% of its field
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Who cites it
57 citing papers in PubMed, 1 synthesis or guideline pooled it, 88 citations in OpenAlex.
- Inactivated vaccine Covaxin/BBV152: A systematic review.Frontiers in immunology · 2022Pooled it
- Efficacy, safety, and lot-to-lot immunogenicity of an inactivated SARS-CoV-2 vaccine (BBV152): interim results of a randomised, double-blind, controlled, phase 3 trial.Lancet (London, England) · 2021Trial
- Exposure route, not dose, is the primary driver of infection patterns for a respiratory virus.Science advances · 2026Article
- Exposure route drives SARS-CoV-2 infection patterns in non-human primates.bioRxiv : the preprint server for biology · 2026Article
- Antiviral Inactivated Vaccines: Looking to the Past to Face the Future-A Narrative Review.Vaccines · 2025Review
- Whole-body visualization of SARS-CoV-2 biodistribution in vivo by immunoPET imaging in non-human primates.Nature communications · 2025Article
- Comprehensive review of preclinical evaluation strategies for COVID-19 vaccine candidates: assessing immunogenicity, toxicology, and safety profiles.Iranian journal of microbiology · 2025Review
- Safety and Immunogenicity Study of a Bivalent Vaccine for Combined Prophylaxis of COVID-19 and Influenza in Non-Human Primates.Vaccines · 2024Article
- Multi-compartmental diversification of neutralizing antibody lineages dissected in SARS-CoV-2 spike-immunized macaques.Nature communications · 2024Article
- Article
- Immunogenicity and efficacy of VLA2001 vaccine against SARS-CoV-2 infection in male cynomolgus macaques.Communications medicine · 2024Article
- The scientific journey of a novel adjuvant (AS37) from bench to bedside.NPJ vaccines · 2024Review
- Review
- Passive antibody therapy in emerging infectious diseases.Frontiers of medicine · 2023Review
- Evaluation of PastoCovac plus vaccine as a booster dose on vaccinated individuals with inactivated COVID-19 vaccine.Heliyon · 2023Article
- Article
- Inactivated and Immunogenic SARS-CoV-2 for Safe Use in Immunoassays and as an Immunization Control for Non-Clinical Trials.Viruses · 2023Article
- Review
- Article
- An inactivated SARS-CoV-2 vaccine induced cross-neutralizing persisting antibodies and protected against challenge in small animals.iScience · 2023Article
Corrections and comments
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Authors and funding
45 authors at 7 institutions in 1 country.
Pragya D YadavIndian Council of Medical Research-National Institute of Virology, Pune, 411021, Maharashtra, India.ORCID 0000-0002-0861-7166
Raches EllaBharat Biotech International Limited, Genome Valley, Hyderabad, 500 078, Telangana, India.ORCID 0000-0002-4646-4471
Sanjay KumarDepartment of Neurosurgery, Command Hospital (Southern Command), Armed Forces Medical College (AFMC), Pune, 411040, Maharashtra, India.ORCID 0000-0002-6568-1148
Dilip R PatilIndian Council of Medical Research-National Institute of Virology, Pune, 411021, Maharashtra, India.ORCID 0000-0002-3610-1378
Sreelekshmy MohandasIndian Council of Medical Research-National Institute of Virology, Pune, 411021, Maharashtra, India.ORCID 0000-0001-9254-2736
Anita M SheteIndian Council of Medical Research-National Institute of Virology, Pune, 411021, Maharashtra, India.ORCID 0000-0003-2625-3703
Krishna M VadrevuBharat Biotech International Limited, Genome Valley, Hyderabad, 500 078, Telangana, India.
Gaurav BhatiArmy Institute of Cardio-Thoracic Sciences, Pune, 411040, Maharashtra, India.ORCID 0000-0002-5261-4675
Gajanan SapkalIndian Council of Medical Research-National Institute of Virology, Pune, 411021, Maharashtra, India.
Himanshu KaushalIndian Council of Medical Research-National Institute of Virology, Pune, 411021, Maharashtra, India.ORCID 0000-0003-0935-9039
Savita PatilIndian Council of Medical Research-National Institute of Virology, Pune, 411021, Maharashtra, India.ORCID 0000-0002-8358-1271
Rajlaxmi JainIndian Council of Medical Research-National Institute of Virology, Pune, 411021, Maharashtra, India.ORCID 0000-0001-6308-3876
Gururaj DeshpandeIndian Council of Medical Research-National Institute of Virology, Pune, 411021, Maharashtra, India.ORCID 0000-0001-6946-4469
Nivedita GuptaIndian Council of Medical Research, V. Ramalingaswami Bhawan, New Delhi, 110029, India.
Kshitij AgarwalIndian Council of Medical Research, V. Ramalingaswami Bhawan, New Delhi, 110029, India.ORCID 0000-0003-0722-1490
Mangesh GokhaleIndian Council of Medical Research-National Institute of Virology, Pune, 411021, Maharashtra, India.
Basavaraj MathapatiIndian Council of Medical Research-National Institute of Virology, Pune, 411021, Maharashtra, India.ORCID 0000-0002-0144-4434
Siddhanath MetkariICMR-National Institute for Research in Reproductive Health, Mumbai, 400012, Maharashtra, India.ORCID 0000-0001-9179-2004
Chandrashekhar MoteDepartment of Veterinary Pathology, Krantisinh Nana Patil College of Veterinary Science, Shirwal, 412801, Maharashtra, India.ORCID 0000-0002-3315-1812
Dimpal NyayanitIndian Council of Medical Research-National Institute of Virology, Pune, 411021, Maharashtra, India.ORCID 0000-0002-1378-6108
Deepak Y PatilIndian Council of Medical Research-National Institute of Virology, Pune, 411021, Maharashtra, India.ORCID 0000-0002-8049-2871
B S Sai PrasadBharat Biotech International Limited, Genome Valley, Hyderabad, 500 078, Telangana, India.ORCID 0000-0002-5546-3673
Annasaheb SuryawanshiIndian Council of Medical Research-National Institute of Virology, Pune, 411021, Maharashtra, India.ORCID 0000-0002-9080-535X
Manoj KadamIndian Council of Medical Research-National Institute of Virology, Pune, 411021, Maharashtra, India.ORCID 0000-0003-2684-6920
Abhimanyu KumarIndian Council of Medical Research-National Institute of Virology, Pune, 411021, Maharashtra, India.ORCID 0000-0003-1513-4768
Sachin DaigudeIndian Council of Medical Research-National Institute of Virology, Pune, 411021, Maharashtra, India.ORCID 0000-0002-9690-3970
Sanjay GopaleIndian Council of Medical Research-National Institute of Virology, Pune, 411021, Maharashtra, India.ORCID 0000-0002-0048-1145
Triparna MajumdarIndian Council of Medical Research-National Institute of Virology, Pune, 411021, Maharashtra, India.ORCID 0000-0002-6873-4073
Deepak MaliIndian Council of Medical Research-National Institute of Virology, Pune, 411021, Maharashtra, India.ORCID 0000-0003-4684-4201
Prasad SarkaleIndian Council of Medical Research-National Institute of Virology, Pune, 411021, Maharashtra, India.ORCID 0000-0003-3228-5285
Shreekant BaradkarIndian Council of Medical Research-National Institute of Virology, Pune, 411021, Maharashtra, India.ORCID 0000-0002-3242-4233
Pranita GawandeIndian Council of Medical Research-National Institute of Virology, Pune, 411021, Maharashtra, India.ORCID 0000-0001-8683-832X
Yash JoshiIndian Council of Medical Research-National Institute of Virology, Pune, 411021, Maharashtra, India.ORCID 0000-0002-6626-1137
Sidharam FulariIndian Council of Medical Research-National Institute of Virology, Pune, 411021, Maharashtra, India.ORCID 0000-0002-4424-4889
Hitesh DigheIndian Council of Medical Research-National Institute of Virology, Pune, 411021, Maharashtra, India.
Sharda SharmaIndian Council of Medical Research-National Institute of Virology, Pune, 411021, Maharashtra, India.
Rashmi GunjikarIndian Council of Medical Research-National Institute of Virology, Pune, 411021, Maharashtra, India.
Abhinendra KumarIndian Council of Medical Research-National Institute of Virology, Pune, 411021, Maharashtra, India.
Kaumudi KaleleIndian Council of Medical Research-National Institute of Virology, Pune, 411021, Maharashtra, India.ORCID 0000-0002-1940-1176
Vellimedu K SrinivasBharat Biotech International Limited, Genome Valley, Hyderabad, 500 078, Telangana, India.
Raman R GangakhedkarIndian Council of Medical Research, V. Ramalingaswami Bhawan, New Delhi, 110029, India.
Krishna M EllaBharat Biotech International Limited, Genome Valley, Hyderabad, 500 078, Telangana, India.ORCID 0000-0002-0021-5082
Priya AbrahamIndian Council of Medical Research-National Institute of Virology, Pune, 411021, Maharashtra, India.
Samiran PandaIndian Council of Medical Research, V. Ramalingaswami Bhawan, New Delhi, 110029, India.ORCID 0000-0002-5077-6275
Balram BhargavaIndian Council of Medical Research, V. Ramalingaswami Bhawan, New Delhi, 110029, India. balrambhargava@yahoo.com.ORCID 0000-0002-1707-1361
ICMR-National Institute of Virology · INBharat Biotech (India) · INIndian Council of Medical Research · INCommand Hospital · INIndian Army · INKrantisinh Nana Patil College of Veterinary Science · INNational Institute for Research in Reproductive Health · IN
Funding
No grant is acknowledged in the PubMed record.
Abstract
The COVID-19 pandemic is a global health crisis that poses a great challenge to the public health system of affected countries. Safe and effective vaccines are needed to overcome this crisis. Here, we develop and assess the protective efficacy and immunogenicity of an inactivated SARS-CoV-2 vaccine in rhesus macaques. Twenty macaques were divided into four groups of five animals each. One group was administered a placebo, while three groups were immunized with three different vaccine candidates of BBV152 at 0 and 14 days. All the macaques were challenged with SARS-CoV-2 fourteen days after the second dose. The protective response was observed with increasing SARS-CoV-2 specific IgG and neutralizing antibody titers from 3
Indexed as
AnimalsAntibodies, NeutralizingAntibodies, ViralCOVID-19 VaccinesEnzyme-Linked Immunosorbent AssayFemaleImmunohistochemistryLymphocytesMacaca mulattaMalePneumoniaSARS-CoV-2Antibodies, NeutralizingAntibodies, ViralCOVID-19 Vaccines
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.