ArticleNPJ Parkinson's disease2021
Rheumatoid arthritis decreases risk for Parkinson's disease: a Mendelian randomization study.
Article in NPJ Parkinson's disease, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 3 syntheses or guidelines pooled it, 44 citations in OpenAlex.
- The association between Parkinson's disease and autoimmune diseases: A systematic review and meta-analysis.Frontiers in immunology · 2023Pooled it
- Association Between Rheumatoid Arthritis and Risk of Parkinson's Disease: A Meta-Analysis and Systematic Review.Frontiers in neurology · 2022Pooled it
- Inflammatory rheumatic diseases and the risk of Parkinson's disease: A systematic review and meta-analysis.Frontiers in neurology · 2022Pooled it
- Systematic Multi-Level Analyses Decode the Arthritis-Neurodegeneration Axis With In Vivo Validation.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Review
- Concomitant Pathologies and Their Impact on Parkinson Disease: A Narrative Overview of Current Evidence.International journal of molecular sciences · 2025Review
- Hearing loss is not associated with risk of Parkinson's disease: A Mendelian randomization study.Heliyon · 2024Article
- Causal relationships between type 1 diabetes mellitus and Alzheimer's disease and Parkinson's disease: a bidirectional two-sample Mendelian randomization study.European journal of medical research · 2024Article
- Causal relationships between rheumatoid arthritis and neurodegenerative diseases: a two-sample univariable and multivariable Mendelian randomization study.Frontiers in medicine · 2024Article
- Chronic diseases and multimorbidity patterns, their recent onset, and risk of new-onset Parkinson's disease and related functional degeneration in older adults: a prospective cohort study.EClinicalMedicine · 2023Article
- Genome-wide analyses identify NEAT1 as genetic modifier of age at onset of amyotrophic lateral sclerosis.Molecular neurodegeneration · 2023Article
- Bidirectional Mendelian randomization analysis of the genetic association between primary lung cancer and colorectal cancer.Journal of translational medicine · 2023Article
- Innate and adaptive immune abnormalities underlying autoimmune diseases: the genetic connections.Science China. Life sciences · 2023Review
- Does Having Rheumatoid Arthritis Increase the Dose of Depression Medications? A Mendelian Randomization Study.Journal of clinical medicine · 2023Article
- Association between air pollution and primary liver cancer in European and east Asian populations: a Mendelian randomization study.Frontiers in public health · 2023Article
- Sex hormones and risk of epilepsy: A bidirectional Mendelian randomization study.Frontiers in molecular neuroscience · 2023Article
- Associations of 10 dietary habits with breast cancer: a Mendelian randomization study.Frontiers in nutrition · 2023Article
- Bidirectional Mendelian randomization analysis investigating the genetic association between primary breast cancer and colorectal cancer.Frontiers in immunology · 2023Article
- A Mendelian randomization study investigating the causal role of inflammation on Parkinson's disease.Brain : a journal of neurology · 2022Article
- Bacterial Butyrate in Parkinson's Disease Is Linked to Epigenetic Changes and Depressive Symptoms.Movement disorders : official journal of the Movement Disorder Society · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Epidemiological and clinical studies have suggested comorbidity between rheumatoid arthritis and Parkinson's disease (PD), but whether there exists a causal association and the effect direction of rheumatoid arthritis on PD is controversial and elusive. To evaluate the causal relationship, we first estimated the genetic correlation between rheumatoid arthritis and PD, and then performed a two-sample Mendelian randomization analysis based on summary statistics from large genome-wide association studies of rheumatoid arthritis (N = 47,580) and PD (N = 482,703). We identified negative and significant correlation between rheumatoid arthritis and PD (genetic correlation: -0.10, P = 0.0033). Meanwhile, one standard deviation increase in rheumatoid arthritis risk was associated with a lower risk of PD (OR: 0.904, 95% CI: 0.866-0.943, P: 2.95E-06). The result was robust under all sensitivity analyses. Our results provide evidence supporting a protective role of rheumatoid arthritis on PD. A deeper understanding of the inflammation and immune response is likely to elucidate the potential pathogenesis of PD and identify therapeutic targets for PD.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.