Evidence map›Paper›PMID 33653955›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2021

Pericytes regulate vascular immune homeostasis in the CNS.

Orsolya Török, Bettina Schreiner, Johanna Schaffenrath, Hsing-Chuan Tsai, Upasana Maheshwari, Sebastian A Stifter, Christina Welsh, Ana Amorim, Sucheta Sridhar, Sebastian G Utz and 8 more

Open access · bronzeAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 118 papers.

0numbers the graph read from it
0cells of the map it votes in
118citing papers in PubMed
11.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

118 citing papers in PubMed, 158 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Review
  6. Review
  7. Review
  8. Review
  9. Review
  10. Vascular basement membrane laminins modulate functional zonation of cerebral microvessels.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2026
    Article
  11. Article
  12. Review
  13. Review
  14. Article
  15. Article
  16. Development of the blood-brain barrier.Development (Cambridge, England) · 2026
    Review
  17. Article
  18. Article
  19. Review
  20. Article

58 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 4 institutions in 2 countries.

Orsolya TörökDepartment of Neurosurgery, Clinical Neuroscience Center, University Hospital Zürich, Zürich University, 8091 Zürich, Switzerland.
Bettina SchreinerInstitute of Experimental Immunology, University of Zürich, 8057 Zürich, Switzerland.
Johanna SchaffenrathDepartment of Neurosurgery, Clinical Neuroscience Center, University Hospital Zürich, Zürich University, 8091 Zürich, Switzerland.ORCID 0000-0003-1689-1648
Hsing-Chuan TsaiDepartment of Neurology and Neurological Sciences, Stanford University, Stanford, CA 94305.ORCID 0000-0001-8972-7174
Upasana MaheshwariDepartment of Neurosurgery, Clinical Neuroscience Center, University Hospital Zürich, Zürich University, 8091 Zürich, Switzerland.ORCID 0000-0001-7516-3099
Sebastian A StifterInstitute of Experimental Immunology, University of Zürich, 8057 Zürich, Switzerland.
Christina WelshInstitute of Experimental Immunology, University of Zürich, 8057 Zürich, Switzerland.ORCID 0000-0001-9802-725X
Ana AmorimInstitute of Experimental Immunology, University of Zürich, 8057 Zürich, Switzerland.ORCID 0000-0002-1708-0452
Sucheta SridharDepartment of Neurosurgery, Clinical Neuroscience Center, University Hospital Zürich, Zürich University, 8091 Zürich, Switzerland.ORCID 0000-0003-2699-0367
Sebastian G UtzInstitute of Experimental Immunology, University of Zürich, 8057 Zürich, Switzerland.
Wiebke MildenbergerInstitute of Experimental Immunology, University of Zürich, 8057 Zürich, Switzerland.
Sina NassiriBioinformatics Core Facility, Swiss Institute of Bioinformatics, 1015 Lausanne, Switzerland.
Mauro DelorenziBioinformatics Core Facility, Swiss Institute of Bioinformatics, 1015 Lausanne, Switzerland.
Adriano AguzziInstitute of Neuropathology, University Hospital Zürich, 8091 Zürich, Switzerland.ORCID 0000-0002-0344-6708
May H HanDepartment of Neurology and Neurological Sciences, Stanford University, Stanford, CA 94305.
Melanie GreterInstitute of Experimental Immunology, University of Zürich, 8057 Zürich, Switzerland.ORCID 0000-0002-7220-5369
Burkhard BecherInstitute of Experimental Immunology, University of Zürich, 8057 Zürich, Switzerland.ORCID 0000-0002-1541-7867
Annika KellerDepartment of Neurosurgery, Clinical Neuroscience Center, University Hospital Zürich, Zürich University, 8091 Zürich, Switzerland; annika.keller@usz.ch.ORCID 0000-0003-1466-3633
University of Zurich · CHSIB Swiss Institute of Bioinformatics · CHStanford University · USUniversity Hospital of Zurich · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Pericytes regulate the development of organ-specific characteristics of the brain vasculature such as the blood-brain barrier (BBB) and astrocytic end-feet. Whether pericytes are involved in the control of leukocyte trafficking in the adult central nervous system (CNS), a process tightly regulated by CNS vasculature, remains elusive. Using adult pericyte-deficient mice (

Indexed as

AnimalsBlood-Brain BarrierEncephalomyelitis, Autoimmune, ExperimentalHomeostasisIntercellular Adhesion Molecule-1LeukocytesMiceMice, TransgenicPericytesProto-Oncogene Proteins c-sisVascular Cell Adhesion Molecule-1Icam1 protein, mouseIntercellular Adhesion Molecule-1Proto-Oncogene Proteins c-sisVascular Cell Adhesion Molecule-1autoimmune neuroinflammationblood–brain barrierleukocyte traffickingMOG35–55–specific T cell receptorpericyte

Identifiers

PMID33653955
PMCPMC7958247
OpenAlexW3134181834

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.