Evidence map›Paper›PMID 33653939›Full record

ArticlemSystems2021

Sputum Proteome Signatures of Mechanically Ventilated Intensive Care Unit Patients Distinguish Samples with or without Anti-pneumococcal Activity.

Jolien Seinen, Rudolf Engelke, Mohammed R Abdullah, Franziska Voß, Stephan Michalik, Vishnu M Dhople, Willem Dieperink, Anne Marie G A de Smet, Uwe Völker, Jan Maarten van Dijl and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in mSystems, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Jolien SeinenDepartment of Medical Microbiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Rudolf EngelkeProteomics Core, Weill Cornell Medicine-Qatar, Education City, Doha, Qatar.
Mohammed R AbdullahDepartment of Molecular Genetics and Infection Biology, Interfaculty Institute for Genetics and Functional Genomics, Center for Functional Genomics of Microbes, University of Greifswald, Greifswald, Germany.
Franziska VoßDepartment of Molecular Genetics and Infection Biology, Interfaculty Institute for Genetics and Functional Genomics, Center for Functional Genomics of Microbes, University of Greifswald, Greifswald, Germany.
Stephan MichalikDepartment of Functional Genomics, Interfaculty Institute for Genetics and Functional Genomics, Center for Functional Genomics of Microbes, University Medicine Greifswald, Greifswald, Germany.ORCID https://orcid.org/0000-0002-6550-0132
Vishnu M DhopleDepartment of Functional Genomics, Interfaculty Institute for Genetics and Functional Genomics, Center for Functional Genomics of Microbes, University Medicine Greifswald, Greifswald, Germany.
Willem DieperinkDepartment of Critical Care, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Anne Marie G A de SmetDepartment of Critical Care, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Uwe VölkerDepartment of Functional Genomics, Interfaculty Institute for Genetics and Functional Genomics, Center for Functional Genomics of Microbes, University Medicine Greifswald, Greifswald, Germany.
Jan Maarten van DijlDepartment of Medical Microbiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands j.m.van.dijl01@umcg.nl frs4001@qatar-med.cornell.edu.ORCID https://orcid.org/0000-0002-5688-8438
Frank SchmidtProteomics Core, Weill Cornell Medicine-Qatar, Education City, Doha, Qatar j.m.van.dijl01@umcg.nl frs4001@qatar-med.cornell.edu.ORCID https://orcid.org/0000-0001-5406-3988
Sven HammerschmidtDepartment of Molecular Genetics and Infection Biology, Interfaculty Institute for Genetics and Functional Genomics, Center for Functional Genomics of Microbes, University of Greifswald, Greifswald, Germany.ORCID https://orcid.org/0000-0002-6382-6681

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Mechanically ventilated patients are at risk of contracting pneumonia. Therefore, these patients often receive prophylactic systemic antimicrobial therapy. Intriguingly however, a previous study showed that antimicrobial activity in bronchoalveolar aspirates (here referred to as "sputa") from ventilated patients was only partially explained by antibiotic therapy. Here we report that sputa from these patients presented distinct proteome signatures depending on the presence or absence of antimicrobial activity. Moreover, we show that the same distinction applied to antibodies against

Indexed as

antimicrobial peptidesimmunoproteomicsmechanical ventilationproteomicssputumStreptococcus pneumoniae

Identifiers

PMID33653939
PMCPMC8546979

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.