ArticleArthritis research & therapy2021
Incident gout and weight change patterns: a retrospective cohort study of US adults.
Article in Arthritis research & therapy, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Citrus Bergamia and Cynara Cardunculus Reduce Serum Uric Acid in Individuals with Non-Alcoholic Fatty Liver Disease.Medicina (Kaunas, Lithuania) · 2022Trial
- Pear-shaped body types linked to lower risk of gout: genetic evidence from Mendelian randomization.International journal of obesity (2005) · 2025Article
- Assessment of drug induced hyperuricemia and gout risk using the FDA adverse event reporting system.Scientific reports · 2025Article
- Associations of weight change patterns with hyperuricemia risk in U.S. adults.Scientific reports · 2025Article
- Association between TyG-BMI and gout in US adults: evidence from NHANES 2007-2018.Scientific reports · 2025Article
- Burden, trends, and predictions of five major musculoskeletal disorders in China, Japan, and South Korea: analysis based on the Global Burden of Disease Study 2021.Frontiers in public health · 2025Article
- Development and validation of a knowledge, attitude, and practice questionnaire regarding exercise and exergames for obese patients with gout.BMC public health · 2024Article
- Weight change patterns across adulthood are associated with the risk of osteoarthritis: a population-based study.Aging clinical and experimental research · 2024Article
- Article
- Causal Association Between Tea Consumption and Gout: A Mendelian Randomization Study.Current medical science · 2023Article
- Correlation between serum uric acid and body fat distribution in patients with MAFLD.BMC endocrine disorders · 2023Article
- Health and Economic Outcomes Associated With Musculoskeletal Disorders Attributable to High Body Mass Index in 192 Countries and Territories in 2019.JAMA network open · 2023 · on this mapArticle
- Review
- Medical Students' Perspective and Knowledge of Asymptomatic Hyperuricemia and Gout Management: A Cross-Sectional Study.Healthcare (Basel, Switzerland) · 2021Article
- Dietary and Lifestyle-Centered Approach in Gout Care and Prevention.Current rheumatology reports · 2021Review
- Where Epigenetics Meets Food Intake: Their Interaction in the Development/Severity of Gout and Therapeutic Perspectives.Frontiers in immunology · 2021Review
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5 authors.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundAlthough the relationship between obesity and incident gout has been clarified, the influence of weight changes during the transition from early adulthood to midlife and the different weight change patterns in specific age ranges on the incidence of gout in later life remain unknown. Therefore, we aimed to investigate the association between weight change patterns across adulthood and incident gout.
methodsUsing data from the National Health and Nutrition Examination Survey (NHANES), we categorized individuals into four weight change patterns: those who remained obese (stable obese), those who moved from a non-obese body mass index (BMI) to an obese BMI (gaining), those who moved from an obese BMI to a non-obese BMI (losing), and those who remained non-obese (stable non-obese). Incident gout reflected its occurrence over the 10-year follow-up from the recalled midlife weight measure to the time of this survey. Hazard ratios (HRs) and 95% confidence intervals relating weight change patterns to incident gout over the 10-year follow-up period were calculated using Cox models adjusted for covariates. The hypothetical population attributable fraction (PAF) for the weight change patterns was calculated.
resultsAmong our sample of adults aged 40-74 years at their midlife weight measure (n = 11,079), 320 developed gout. The highest risk of incident gout was found for participants with the stable obese pattern (HR 1.84; 1.08-3.14) and not for participants who remained stable non-obese during adulthood. Moreover, gaining weight was a significant risk factor for incident gout (HR 1.65; 1.19-2.29). No significant associations were found between losing weight change patterns and the risk of gout during the study period. If participants who gained weight had become non-obese during the 10-year follow-up, an estimated 3.2% (95% CI 0-6.3) of observed gout cases could have been averted. In addition, if the population had maintained a normal BMI, 32.9% (95% CI 18.2-44.9) cases could have been prevented during the 10 years.
conclusionsGaining weight over adulthood was associated with an increased risk of gout. These findings have highlighted that maintaining non-obese weight and weight loss across adulthood is essential for the prevention and treatment of gout in adult life.
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