Evidence map›Paper›PMID 33653363›Full record

ArticleReproductive biology and endocrinology : RB&E2021

Label-free proteomics uncovers SMC1A expression is Down-regulated in AUB-E.

Yingxian Jia, Jie Luo, Yibing Lan, Chunming Li, Linjuan Ma, Xiaoming Zhu, Fei Ruan, Jianhong Zhou

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Reproductive biology and endocrinology : RB&E, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.8field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Yingxian JiaWomen's Hospital, School of Medicine, Zhejiang University, Zhejiang, China.
Jie LuoWomen's Hospital, School of Medicine, Zhejiang University, Zhejiang, China.
Yibing LanWomen's Hospital, School of Medicine, Zhejiang University, Zhejiang, China.
Chunming LiWomen's Hospital, School of Medicine, Zhejiang University, Zhejiang, China.
Linjuan MaWomen's Hospital, School of Medicine, Zhejiang University, Zhejiang, China.
Xiaoming ZhuWomen's Hospital, School of Medicine, Zhejiang University, Zhejiang, China.
Fei RuanWomen's Hospital, School of Medicine, Zhejiang University, Zhejiang, China. 5202014@zju.edu.cn.
Jianhong ZhouWomen's Hospital, School of Medicine, Zhejiang University, Zhejiang, China. zhoujh1117@zju.edu.cn.
Women's Hospital, School of Medicine, Zhejiang University · CN

Funding

Zhejiang Provincial Department of Science and Technology 2019C03026
6 · The paper itself

Abstract

backgroundWhile heavy menstrual bleeding (HMB) is a prevalent symptom among women with abnormal uterine bleeding caused by endometrial disorder (AUB-E) seeking gynecologic care, the primary endometrial disorder remains poorly understood.

methodsFive human endometrial samples from women with AUB-E and the age-matched healthy women were selected, respectively. Proteins from the samples were analyzed by a linear ion trap (LTQ)-Orbitrap Elite mass spectrometer based label-free proteomic approach. The purpose protein was validated by western blot and immunohistochemistry staining.

resultsA total of 2353 protein groups were quantified under highly stringent criteria with a false discovery rate of < 1% for protein groups, and 291 differentially expressed proteins were significantly changed between the two groups. The results showed that the down-regulation of structural maintenance of chromosomes protein 1A (SMC1A) in AUB-E patients. Next, this change in the glandular epithelial cells was validated by immunohistochemistry.

conclusionThe results indicated a novel mechanism for the cause of AUB-E, as down-expression SMC1A potentially regulated the cell cycle progression in endometrial glandular epithelium further led to bleeding.

Indexed as

Down-RegulationAdultCell Cycle ProteinsChromosomal Proteins, Non-HistoneEndometriumFemaleHumansMenstruation DisturbancesProteomicsStructural Maintenance of Chromosome Protein 1Cell Cycle ProteinsChromosomal Proteins, Non-HistoneStructural Maintenance of Chromosome Protein 1Abnormal uterine bleedingHuman endometriumPrimary endometrial disorderProteomic analysis

Identifiers

PMID33653363
PMCPMC7923474
OpenAlexW3134534357

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.