ArticleBMC pulmonary medicine2021
The association between eosinophilic exacerbation and eosinophilic levels in stable COPD.
Article in BMC pulmonary medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 16 citations in OpenAlex.
- Clinical and Inflammatory Phenotypes During Exacerbations Predict In-Hospital Adverse Outcomes in Asthma-COPD Overlap.Respirology (Carlton, Vic.) · 2026Article
- Article
- Inflammatory phenotype drives different immunosuppressive response in COPD exacerbations.BMC pulmonary medicine · 2026Article
- Systemic inflammation, microbiology, and clinical outcomes in eosinophilic and non-eosinophilic acute exacerbations of chronic obstructive pulmonary disease.Frontiers in medicine · 2026Article
- Role of IL-5 in eosinophil-associated diseases and prospects for multi-target therapy.Frontiers in immunology · 2026Review
- The Association Between the Eosinophilic COPD Phenotype with Overall Survival and Exacerbations in Patients on Long-Term Non-Invasive Ventilation.Biomolecules · 2025Article
- Implication of Admission Eosinophil Count and Prognosis of Coronavirus Disease 2019 (COVID-19) in Elderly Patients With COPD: A Territory-Wide Cohort Study.The clinical respiratory journal · 2025Article
- Comparing Heterogenous Phenotypes of Chronic Obstructive Pulmonary Disease: Network Analysis and Penalized Generalized Linear Model.International journal of chronic obstructive pulmonary disease · 2025Article
- No evidence for additional systemic eosinophil mobilization during exacerbations in patients with COPD and chronic bronchitis but no allergy.Frontiers in medicine · 2025Article
- Impact of blood eosinophil count on clinical outcomes in hospitalized Syrian patients with COPD exacerbation.The Journal of international medical research · 2024Article
- Prediction value of neutrophil and eosinophil count at risk of COPD exacerbation.Annals of medicine · 2023Article
- Using inflammatory index to distinguish asthma, asthma-COPD overlap and COPD: A retrospective observational study.Frontiers in medicine · 2022Article
- COPD Exacerbation Syndrome: The Spanish Perspective on an Old Dilemma.International journal of chronic obstructive pulmonary disease · 2022Review
- Phenotyping acute exacerbation of COPD: what more can we do for hospitalised patients?ERJ open research · 2021Article
- The influence of individual characteristics and non-respiratory diseases on blood eosinophil count.Clinical and translational allergy · 2021Article
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundBlood eosinophil count may predict treatment response in patients with chronic obstructive pulmonary disease (COPD) during acute exacerbations (AE). However, the ability and thresholds of blood eosinophil counts in stable status to predict eosinophilic AECOPD have not been completely investigated.
methodsThis was a retrospective multicenter study performed January 2010 to December 2014. COPD subjects hospitalized with exacerbations, were included. Blood samples were obtained at the time of AE and stable disease at outpatient clinic before or after admission. We identified a blood eosinophil count cut-off point at stable COPD, either taken as a percentage or as absolute value, for identification of eosinophilic exacerbation.
resultsThere was significant positive correlation of eosinophil counts between stable COPD and AECOPD. The best cut-off value of blood eosinophil count in stable status for the prediction of eosinophilic COPD exacerbation based on blood eosinophil count ≥ 2% was 300 cells/µL (area under the ROC curve [AUC] 0.614, P = 0.001, 39% sensitivity, 83.8% specificity). When the eosinophilic COPD exacerbation was based on blood eosinophil count ≥ 300 cells/µL, the best cut-off value of blood eosinophil count in stable status for the prediction of eosinophilic COPD exacerbation was also 300 cells/uL (AUC 0.634, P = 0.046, 45.8% sensitivity, 80.9% specificity).
conclusionsWe demonstrated association between blood eosinophil counts at stable COPD and those with AECOPD. The thresholds of blood counts at stable COPD to predict eosinophilic exacerbations was 300 cells/µL. Further and prospective studies in other populations should validate our results.
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