ReviewProceedings. Biological sciences2021
Perspective on musculoskeletal modelling and predictive simulations of human movement to assess the neuromechanics of gait.
Review in Proceedings. Biological sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 66 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
66 citing papers in PubMed, 155 citations in OpenAlex.
- Simulation study of exoskeleton-musculoskeletal coupling for exoskeleton assistance via multi-agent reinforcement learning.Medical & biological engineering & computing · 2026Article
- Unified comparison of spinal locomotion control architectures in neuromechanical simulations.bioRxiv : the preprint server for biology · 2026Article
- Predictive Neuromechanical Simulation Explains Gait Biomechanics in Obesity.bioRxiv : the preprint server for biology · 2026Article
- Exploring the effect of different neural strategies on the knee joint contact forces during walking in adults.Scientific reports · 2026Article
- How muscle ageing affects rapid goal-directed movement: mechanistic insights from a simple model.PLoS computational biology · 2026Article
- A model of the cerebellum generates gait adaptations in a reflex-based neuromusculoskeletal model during split-belt walking.Journal of neuroengineering and rehabilitation · 2025Article
- A model of the cerebellum generates gait adaptations in a reflex-based neuromusculoskeletal model during split-belt walking.bioRxiv : the preprint server for biology · 2025Article
- Advancements in Understanding Spasticity: A Neuromusculoskeletal Modeling Perspective.Journal of clinical medicine · 2025Review
- Natural variability can increase human walking metabolic costs and its implications to simulation-based metabolic estimation.Journal of the Royal Society, Interface · 2025Article
- Estimating the contribution of musculoskeletal impairments to altered gait kinematics in children with cerebral palsy using predictive simulations.Journal of neuroengineering and rehabilitation · 2025Article
- A physiologically inspired hybrid CPG/Reflex controller for cycling simulations that generalizes to walking.PLoS computational biology · 2025Article
- A PRISMA systematic review through time on predictive musculoskeletal simulations.Journal of neuroengineering and rehabilitation · 2025Article
- EMG-Informed Neuromusculoskeletal Simulations Increase the Accuracy of the Estimation of Knee Joint Contact Forces During Sub-optimal Level Walking.Annals of biomedical engineering · 2025Article
- Muscle weakness but also contractures contribute to the progressive gait pathology in children with Duchenne muscular dystrophy: a simulation study.Journal of neuroengineering and rehabilitation · 2025Article
- Exploring the accuracy of palaeobiological modelling procedures in forward-dynamics simulations of maximum-effort vertical jumping.Royal Society open science · 2025Article
- Emergence of natural and robust bipedal walking by learning from biologically plausible objectives.iScience · 2025Article
- Motor modules are largely unaffected by pathological walking biomechanics: a simulation study.Journal of neuroengineering and rehabilitation · 2025Article
- Biomechanical models in the lower-limb exoskeletons development: a review.Journal of neuroengineering and rehabilitation · 2025Review
- Dynamic biomechanical effects of medial meniscus tears on the knee joint: a finite element analysis.Journal of orthopaedic surgery and research · 2025Article
- Design optimization platform for assistive wearable devices applied to a knee damper exoskeleton.Wearable technologies · 2025Article
6 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Locomotion results from complex interactions between the central nervous system and the musculoskeletal system with its many degrees of freedom and muscles. Gaining insight into how the properties of each subsystem shape human gait is challenging as experimental methods to manipulate and assess isolated subsystems are limited. Simulations that predict movement patterns based on a mathematical model of the neuro-musculoskeletal system without relying on experimental data can reveal principles of locomotion by elucidating cause-effect relationships. New computational approaches have enabled the use of such predictive simulations with complex neuro-musculoskeletal models. Here, we review recent advances in predictive simulations of human movement and how those simulations have been used to deepen our knowledge about the neuromechanics of gait. In addition, we give a perspective on challenges towards using predictive simulations to gain new fundamental insight into motor control of gait, and to help design personalized treatments in patients with neurological disorders and assistive devices that improve gait performance. Such applications will require more detailed neuro-musculoskeletal models and simulation approaches that take uncertainty into account, tools to efficiently personalize those models, and validation studies to demonstrate the ability of simulations to predict gait in novel circumstances.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.