Evidence map›Paper›PMID 33652986›Full record

ArticleInternational journal of molecular sciences2021

Effects of Structural Isomers of Spermine on the Higher-Order Structure of DNA and Gene Expression.

Tomoki Kitagawa, Takashi Nishio, Yuko Yoshikawa, Naoki Umezawa, Tsunehiko Higuchi, Chwen-Yang Shew, Takahiro Kenmotsu, Kenichi Yoshikawa

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.8field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Spatial-Temporal Genome Regulation in Stress-Response and Cell-Fate Change.International journal of molecular sciences · 2023
    Review
  6. Article
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Tomoki KitagawaGraduate School of Life and Medical Sciences, Doshisha University, Kyoto 610-0394, Japan.
Takashi NishioGraduate School of Life and Medical Sciences, Doshisha University, Kyoto 610-0394, Japan.ORCID 0000-0001-8761-1776
Yuko YoshikawaGraduate School of Life and Medical Sciences, Doshisha University, Kyoto 610-0394, Japan.
Naoki UmezawaGraduate School of Pharmaceutical Sciences, Nagoya City University, Nagoya 467-8603, Japan.
Tsunehiko HiguchiGraduate School of Pharmaceutical Sciences, Nagoya City University, Nagoya 467-8603, Japan.ORCID 0000-0002-3586-4680
Chwen-Yang ShewDoctoral Program in Chemistry, The Graduate Center of the City University of New York, New York, NY 10016, USA.
Takahiro KenmotsuGraduate School of Life and Medical Sciences, Doshisha University, Kyoto 610-0394, Japan.
Kenichi YoshikawaGraduate School of Life and Medical Sciences, Doshisha University, Kyoto 610-0394, Japan.ORCID 0000-0002-2751-7136
Doshisha University · JPNagoya City University · JPThe Graduate Center, CUNY · US

Funding

Japan Society for the Promotion of Science JP20H05934, JP20H01877
6 · The paper itself

Abstract

Polyamines are involved in various biological functions, including cell proliferation, differentiation, gene regulation, etc. Recently, it was found that polyamines exhibit biphasic effects on gene expression: promotion and inhibition at low and high concentrations, respectively. Here, we compared the effects of three naturally occurring tetravalent polyamines, spermine (SPM), thermospermine (TSPM), and

Indexed as

Gene Expression Regulation, ViralBacteriophage T4DNA, ViralIsomerismModels, MolecularNucleic Acid ConformationSpermineDNA, ViralSperminethermosperminebimodal effect of promotion and inhibitiongene expressionhigher-order structure of DNApolyamine

Identifiers

PMID33652986
PMCPMC7956460
OpenAlexW3135157690

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.