Evidence map›Paper›PMID 33652955›Full record

ArticleSensors (Basel, Switzerland)2021

Development of Flexible Ion-Selective Electrodes for Saliva Sodium Detection.

Hyo-Ryoung Lim, Soon Min Lee, Musa Mahmood, Shinjae Kwon, Yun-Soung Kim, Yongkuk Lee, Woon-Hong Yeo

Abstract read
In one paragraph

Article in Sensors (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Hyo-Ryoung LimGeorge W. Woodruff School of Mechanical Engineering, Center for Human-Centric Interfaces and Engineering, Institute for Electronics and Nanotechnology, Georgia Institute of Technology, Atlanta, GA 30332, USA.ORCID 0000-0002-0828-2853
Soon Min LeeDepartment of Pediatrics, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul 06273, Korea.ORCID 0000-0003-0174-1065
Musa MahmoodGeorge W. Woodruff School of Mechanical Engineering, Center for Human-Centric Interfaces and Engineering, Institute for Electronics and Nanotechnology, Georgia Institute of Technology, Atlanta, GA 30332, USA.
Shinjae KwonGeorge W. Woodruff School of Mechanical Engineering, Center for Human-Centric Interfaces and Engineering, Institute for Electronics and Nanotechnology, Georgia Institute of Technology, Atlanta, GA 30332, USA.
Yun-Soung KimGeorge W. Woodruff School of Mechanical Engineering, Center for Human-Centric Interfaces and Engineering, Institute for Electronics and Nanotechnology, Georgia Institute of Technology, Atlanta, GA 30332, USA.ORCID 0000-0002-3892-7560
Yongkuk LeeDepartment of Biomedical Engineering, Wichita State University, Wichita, KS 67260, USA.ORCID 0000-0001-8452-2225
Woon-Hong YeoGeorge W. Woodruff School of Mechanical Engineering, Center for Human-Centric Interfaces and Engineering, Institute for Electronics and Nanotechnology, Georgia Institute of Technology, Atlanta, GA 30332, USA.ORCID 0000-0002-5526-3882

Funding

Ministry of Science and ICT, South Korea IITP-2020-0-01517Yonsei University College of Medicine 6-2019-0169
6 · The paper itself

Abstract

Saliva can be used for health monitoring with non-invasive wearable systems. Such devices, including electrochemical sensors, may provide a safe, fast, and cost-efficient way of detecting target ions. Although salivary ions are known to reflect those in blood, no available clinical device can detect essential ions directly from saliva. Here, we introduce an all-solid-state, flexible film sensor that allows highly accurate detection of sodium levels in saliva, comparable to those in blood. The wireless film sensor system can successfully measure sodium ions from a small volume of infants' saliva (<400 µL), demonstrating its potential as a continuous health monitor. This study includes the structural characterization and error analysis of a carbon/elastomer-based ion-selective electrode and a reference electrode to confirm the signal reliability. The sensor, composed of a pair of the electrodes, shows good sensitivity (58.9 mV/decade) and selectivity (log K = -2.68 for potassium), along with a broad detection range of 5 × 10

Indexed as

Biosensing TechniquesSodiumElectrodesHumansInfantIonsIon-Selective ElectrodesReproducibility of ResultsSalivaIonsSodiumelectrochemical sensorion-selective electrodenon-invasive diagnosissaliva-to-blood sodium levels

Identifiers

PMID33652955
PMCPMC7956447

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.