Evidence map›Paper›PMID 33652925›Full record

ArticleMolecules (Basel, Switzerland)2021

Structure Elucidation and Cholinesterase Inhibition Activity of Two New Minor Amaryllidaceae Alkaloids.

Jana Maříková, Abdullah Al Mamun, Latifah Al Shammari, Jan Korábečný, Tomáš Kučera, Daniela Hulcová, Jiří Kuneš, Milan Malaník, Michaela Vašková, Eliška Kohelová and 3 more

Abstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Jana MaříkováDepartment of Bioorganic and Organic Chemistry, Faculty of Pharmacy, Charles University, Heyrovskeho 1203, 500 05 Hradec Kralove, Czech Republic.
Abdullah Al MamunADINACO Research Group, Department of Pharmaceutical Botany, Faculty of Pharmacy, Charles University, Heyrovskeho 1203, 500 05 Hradec Kralove, Czech Republic.ORCID 0000-0002-3441-8814
Latifah Al ShammariADINACO Research Group, Department of Pharmaceutical Botany, Faculty of Pharmacy, Charles University, Heyrovskeho 1203, 500 05 Hradec Kralove, Czech Republic.
Jan KorábečnýDepartment of Toxicology and Military Pharmacy, University of Defence, Trenesska 1575, 500 05 Hradec Kralove, Czech Republic.
Tomáš KučeraDepartment of Toxicology and Military Pharmacy, University of Defence, Trenesska 1575, 500 05 Hradec Kralove, Czech Republic.ORCID 0000-0001-6650-1738
Daniela HulcováADINACO Research Group, Department of Pharmaceutical Botany, Faculty of Pharmacy, Charles University, Heyrovskeho 1203, 500 05 Hradec Kralove, Czech Republic.
Jiří KunešDepartment of Bioorganic and Organic Chemistry, Faculty of Pharmacy, Charles University, Heyrovskeho 1203, 500 05 Hradec Kralove, Czech Republic.
Milan MalaníkDepartment of Natural Drugs, Faculty of Pharmacy, Masaryk University, Palackeho trida 1946/1, 612 00 Brno, Czech Republic.ORCID 0000-0001-8700-8416
Michaela VaškováDepartment of Chemistry, Faculty of Science, University of Hradec Kralove, Rokitanskeho 62, 500 03 Hradec Kralove, Czech Republic.
Eliška KohelováADINACO Research Group, Department of Pharmaceutical Botany, Faculty of Pharmacy, Charles University, Heyrovskeho 1203, 500 05 Hradec Kralove, Czech Republic.
Lucie NovákováDepartment of Analytical Chemistry, Faculty of Pharmacy, Charles University, Heyrovskeho 1203, 500 05 Hradec Kralove, Czech Republic.ORCID 0000-0003-3570-5871
Lucie CahlíkováADINACO Research Group, Department of Pharmaceutical Botany, Faculty of Pharmacy, Charles University, Heyrovskeho 1203, 500 05 Hradec Kralove, Czech Republic.ORCID 0000-0002-1555-8870
Milan PourDepartment of Bioorganic and Organic Chemistry, Faculty of Pharmacy, Charles University, Heyrovskeho 1203, 500 05 Hradec Kralove, Czech Republic.ORCID 0000-0002-3962-7922

Funding

European Regional Development Fund CZ.02.1.01/0.0/0.0/16_019/0000841Grantová Agentura, Univerzita Karlova SVV UK 260 548, SVV UK 260 547University Hospital Hradec Kralove 00179906University Hradec Králové VT2019-2021
6 · The paper itself

Abstract

Two new minor Amaryllidaceae alkaloids were isolated from

Indexed as

AlkaloidsAlzheimer DiseaseAmaryllidaceae AlkaloidsButyrylcholinesteraseCatalytic DomainCholinesterase InhibitorsCholinesterasesCircular DichroismHumansMolecular Docking SimulationMolecular StructureStructure-Activity RelationshipAlkaloidsAmaryllidaceae AlkaloidsButyrylcholinesteraseCholinesterase InhibitorsCholinesterases9-O-demethyllycorenineAlzheimer’s diseaseAmaryllidaceaenarciabduliine

Identifiers

PMID33652925
PMCPMC7956344

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.