ReviewBiomolecules2021
Oxygen-Ozone Therapy in the Rehabilitation Field: State of the Art on Mechanisms of Action, Safety and Effectiveness in Patients with Musculoskeletal Disorders.
Review in Biomolecules, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 65 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Safety and Effectiveness of Hyaluronic Acid and Sorbitol With Overuse Knee Pain in Sportsmen
Is Intra-articular Injection of High-concentration Ozone (O2-O3) More Effective in Treating Knee Osteoarthritis?: A Multicenter Clinical Trial
Who cites it
65 citing papers in PubMed, 3 syntheses or guidelines pooled it, 109 citations in OpenAlex.
- Ozone injections reduce pain in knee osteoarthritis: a systematic review and meta-analysis.Medical gas research · 2026Pooled it
- The time-effect relationship of intra-articular ozone injection for knee osteoarthritis: a systematic review and meta-analysis.Frontiers in pain research (Lausanne, Switzerland) · 2026Pooled it
- Impact of exercise training on muscle mitochondria modifications in older adults: a systematic review of randomized controlled trials.Aging clinical and experimental research · 2022Pooled it
- Comparison of intra-articular ozone and steroid injection in patients with adhesive capsulitis.Clinical rheumatology · 2025Trial
- Efficacy of two doses of intra-articular ozone therapy for pain and functional mobility in knee osteoarthritis: a double-blind randomized trial.Advances in rheumatology (London, England) · 2025Trial
- Effectiveness of ultrasonography-guided periforaminal oxygen-ozone therapy in chronic low back pain.Turkish journal of medical sciences · 2025Trial
- The efficacy of ultrasonography-guided oxygen-ozone therapy versus corticosteroids in patients with knee osteoarthritis: A multicenter randomized controlled trial.Journal of back and musculoskeletal rehabilitation · 2024Trial
- Ozone Therapy versus Hyaluronic Acid Injections for Pain Relief in Patients with Knee Osteoarthritis: Preliminary Findings on Molecular and Clinical Outcomes from a Randomized Controlled Trial.International journal of molecular sciences · 2023Trial
- Ultrasound-guided injection strategies for lateral epicondylitis: a multicenter randomized comparison of corticosteroid, platelet-rich plasma, and ozone.Future science OA · 2026Article
- Gas therapy: an innovative application for intervertebral disc degeneration.Medical gas research · 2026Review
- Article
- Intra-Articular Ozone Injections for Temporomandibular Joint Disorders: A Systematic Review.Journal of clinical medicine · 2026Review
- The evolving landscape of minimally invasive procedures in musculoskeletal diseases-Part II.Frontiers in medicine · 2026Review
- Ozone as an Immunomodulator-New Therapeutic Possibilities in the Treatment of Immunodeficiencies-A Narrative Review.Current issues in molecular biology · 2025Review
- Retrospective Clinical and Radiological Comparison of Intradiscal Ozone and Ozone + PRP Therapy Results in Patients with Intervertebral Disc Degeneration.Turkish journal of anaesthesiology and reanimation · 2025Article
- Oxygen-Ozone Therapy in Tendinopathy Management: A Comprehensive Review.Journal of personalized medicine · 2025Review
- Ozone Nanobubble Water as a Sustainable Strategy to Enhance Metabolism, Muscle Function, and Exercise Performance in Mice.Nutrients · 2025Article
- Clinical and Microbiological Study on Local Application of an Ozonated Olive Oil Gel in the Periodontal Pockets: A Randomized Double-Blind Trial.Journal of clinical medicine · 2025Article
- Article
- Ozone therapy for knee osteoarthritis: a literature visualization analysis of research hotspots and prospects.Medical gas research · 2025Review
5 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In recent years, the interest in oxygen-ozone (O
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.