Evidence map›Paper›PMID 33652782›Full record

ArticleCancers2021

Rabdosianone I, a Bitter Diterpene from an Oriental Herb, Suppresses Thymidylate Synthase Expression by Directly Binding to ANT2 and PHB2.

Motoki Watanabe, Yasumasa Yamada, Yoichi Kurumida, Tomoshi Kameda, Mamiko Sukeno, Mahiro Iizuka-Ohashi, Yoshihiro Sowa, Yosuke Iizumi, Hideki Takakura, Shingo Miyamoto and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancers, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.4field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

Motoki WatanabeDepartment of Molecular-Targeting Prevention, Kyoto Prefectural University of Medicine, Kyoto 602-8566, Japan.
Yasumasa YamadaDepartment of Food Science and Human Nutrition, Baika Women's University, Osaka 567-8578, Japan.
Yoichi KurumidaArtificial Intelligence Research Center, National Institute of Advanced Industrial Science and Technology (AIST), Tokyo 135-0064, Japan.
Tomoshi KamedaArtificial Intelligence Research Center, National Institute of Advanced Industrial Science and Technology (AIST), Tokyo 135-0064, Japan.ORCID 0000-0001-9508-5366
Mamiko SukenoDrug Discovery Center, Kyoto Prefectural University of Medicine, Kyoto 602-8566, Japan.
Mahiro Iizuka-OhashiDepartment of Molecular-Targeting Prevention, Kyoto Prefectural University of Medicine, Kyoto 602-8566, Japan.
Yoshihiro SowaDepartment of Molecular-Targeting Prevention, Kyoto Prefectural University of Medicine, Kyoto 602-8566, Japan.
Yosuke IizumiDepartment of Molecular-Targeting Prevention, Kyoto Prefectural University of Medicine, Kyoto 602-8566, Japan.
Hideki TakakuraDepartment of Molecular-Targeting Prevention, Kyoto Prefectural University of Medicine, Kyoto 602-8566, Japan.ORCID 0000-0003-3552-6144
Shingo MiyamotoEpidemiology and Prevention Division, Center for Public Health Sciences, National Cancer Center, Tokyo 104-0045, Japan.
Toshiyuki SakaiDrug Discovery Center, Kyoto Prefectural University of Medicine, Kyoto 602-8566, Japan.
Michihiro MutohDepartment of Molecular-Targeting Prevention, Kyoto Prefectural University of Medicine, Kyoto 602-8566, Japan.
Kyoto Prefectural University of Medicine · JPNational Institute of Advanced Industrial Science and Technology · JPBaika Women's University · JP

Funding

the Foundation for Cancer Research supported by Kyoto Preventive Medical Center 30-049
6 · The paper itself

Abstract

Natural products have numerous bioactivities and are expected to be a resource for potent drugs. However, their direct targets in cells often remain unclear. We found that rabdosianone I, which is a bitter diterpene from an oriental herb for longevity,

Indexed as

adenine nucleotide translocase 2chemical biologynatural productsprohibitin 2rabdosianone Ithymidylate synthase

Identifiers

PMID33652782
PMCPMC7956614
OpenAlexW3133514577

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.