Evidence map›Paper›PMID 33652021›Full record

ReviewNeuroscience and biobehavioral reviews2021

Dopamine and the interdependency of time perception and reward.

Bowen J Fung, Elissa Sutlief, Marshall G Hussain Shuler

Abstract readReview
In one paragraph

Review in Neuroscience and biobehavioral reviews, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. The Role of the Serotonergic System in Time Perception: A Systematic Review.International journal of molecular sciences · 2024
    Pooled it
  2. Evidence for pro-cognitive benefits of cannabinoids in people with bipolar disorder.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026
    Trial
  3. Trial
  4. Effort, timing and choice: a refined rodent effort choice task with excellent sensitivity to dopamine modulators.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026
    Article
  5. Article
  6. Review
  7. Article
  8. Time, space, memory and brain-body rhythms.Nature reviews. Neuroscience · 2026
    Review
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  11. Article
  12. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Bowen J FungThe Behavioural Insights Team, Suite 3, Level 13/9 Hunter St, Sydney NSW 2000, Australia. Electronic address: bowen.fung@bi.team.
Elissa SutliefThe Solomon H. Snyder Department of Neuroscience, The Johns Hopkins University School of Medicine, Woods Basic Science Building Rm914, 725 N. Wolfe Street, Baltimore, MD 21205, USA.
Marshall G Hussain ShulerThe Solomon H. Snyder Department of Neuroscience, The Johns Hopkins University School of Medicine, Woods Basic Science Building Rm914, 725 N. Wolfe Street, Baltimore, MD 21205, USA; Kavli Neuroscience Discovery Institute, The Johns Hopkins University School of Medicine, 725 N Wolfe Street, Baltimore, MD 21205, USA. Electronic address: shuler@jhmi.edu.

Funding

The production, learning, and behavioral significance of outcome prediction signaling in the corticostriatal circuitR01MH123446 · NIMH · JOHNS HOPKINS UNIVERSITY · PI SHULER, MARSHALL GILMER · 2020 to 2024
$2.9M
NIMH NIH HHS R01 MH123446
6 · The paper itself

Abstract

Time is a fundamental dimension of our perception of the world and is therefore of critical importance to the organization of human behavior. A corpus of work - including recent optogenetic evidence - implicates striatal dopamine as a crucial factor influencing the perception of time. Another stream of literature implicates dopamine in reward and motivation processes. However, these two domains of research have remained largely separated, despite neurobiological overlap and the apothegmatic notion that "time flies when you're having fun". This article constitutes a review of the literature linking time perception and reward, including neurobiological and behavioral studies. Together, these provide compelling support for the idea that time perception and reward processing interact via a common dopaminergic mechanism.

Indexed as

DopamineTime PerceptionCorpus StriatumHumansMotivationRewardDopamineDopamineMotivationRewardTime perceptionTiming

Identifiers

PMID33652021
PMCPMC9062982

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.