ArticlePloS one2021
Combined pre- and post-capillary pulmonary hypertension: The clinical implications for patients with heart failure.
Article in PloS one, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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14 citing papers in PubMed.
- Fatty Acid and Oxylipin Metabolism Differentiate Isolated Postcapillary From Combined Pre- and Postcapillary Pulmonary Hypertension.Circulation. Heart failure · 2026Article
- Assessment of Right Ventricular Adaptability to Pressure Overloading for Critical Therapeutic Decision-Making Processes.Journal of clinical medicine · 2026Review
- Relationship of cardiac MRI-derived pulmonary arterial stiffness markers and invasive hemodynamic.The international journal of cardiovascular imaging · 2026Article
- The effects of bolus isosorbide dinitrate on pulmonary hypertension with cardiopulmonary comorbidities.Heart and vessels · 2025Article
- Pulmonary artery pressure assessed by catheterization and its concordance with transthoracic echocardiographic estimates in patients with pulmonary arterial hypertension: experience of the Colombian Pulmonary Hypertension Network in a real-life study.Critical care science · 2025Article
- Optimized quantitative mapping of cardiopulmonary oscillations using hyperpolarizedMagnetic resonance in medicine · 2024Article
- Pulmonary artery wave intensity analysis in pulmonary hypertension associated with heart failure and reduced left ventricular ejection fraction.Pulmonary circulation · 2024Article
- Myeloid Cell Derived IL1β Contributes to Pulmonary Hypertension in HFpEF.Circulation research · 2023Article
- Future perspective in diabetic patients with pre- and post-capillary pulmonary hypertension.Heart failure reviews · 2023Review
- Animal models of pulmonary hypertension due to left heart disease.Animal models and experimental medicine · 2022Review
- Unloading the right to fill the left: vasodilation to treat hypotension: a case report.European heart journal. Case reports · 2022Article
- Acute and chronic exercise training in patients with Class II pulmonary hypertension: effects on haemodynamics and symptoms.ESC heart failure · 2022Review
- Measurement of Pulmonary Artery Wave Reflection Before and After Mitral Valvuloplasty in Canine Patients With Pulmonary Hypertension Caused by Myxomatous Mitral Valve Disease.Frontiers in veterinary science · 2021Article
- Clinical Outcomes of Mitral Valve Repair in Dogs With Pulmonary Hypertension Secondary to Myxomatous Mitral Valve Disease.Journal of veterinary internal medicineArticle
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Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe prognostic implications of combined pre- and post-capillary pulmonary hypertension (Cpc-PH) in patients with pulmonary hypertension due to left heart disease (PH-LHD) remain controversial. The aim of this retrospective study was to evaluate the new PH-LHD criteria, recommended by the 6th World Symposium on Pulmonary Hypertension and to determine the prognostic value of Cpc-PH.
methodsA total of 701 patients with symptomatic heart failure who had undergone right-heart catheterization were divided into the following four groups: (i) Isolated post-capillary PH (Ipc-PH) group; mean pulmonary artery pressure (mPAP) >20 mmHg, pulmonary artery wedge pressure (PAWP) >15 mmHg, and pulmonary vascular resistance (PVR) <3 Wood units (WU) (ii) Cpc-PH group; mPAP >20 mmHg, PAWP >15 mmHg, and PVR ≥3 WU (iii) borderline-PH group; mPAP >20 mmHg and PAWP ≤15 mmHg (iv) non-PH group; mPAP ≤20 mmHg. Multivariate Cox hazard analysis was used to investigate whether Cpc-PH was associated with cardiac outcomes.
resultsThe study subjects were allocated into the Ipc-PH (n = 268), Cpc-PH (n = 54), borderline-PH (n = 112), or non-PH (n = 267) groups. The Cpc-PH group was associated significantly with adverse cardiac events even after adjustment for clinically relevant confounding factors for heart failure prognosis (vs. non-PH group: HR 2.98 [95% CI 1.81-4.90], P <0.001; vs. Ipc-PH group: HR: 1.92 [95% CI 1.19-3.08], P = 0.007).
conclusionsThe new definitions of PH-LHD stratified patients into 4 categories. Long-term clinical outcomes were significantly different between the four categories, with Cpc-PH having the worst cardiac outcomes.
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