Evidence map›Paper›PMID 33651646›Full record

ArticleGut microbes

Dietary vitamin K is remodeled by gut microbiota and influences community composition.

Jessie L Ellis, J Philip Karl, Angela M Oliverio, Xueyan Fu, Jason W Soares, Benjamin E Wolfe, Christopher J Hernandez, Joel B Mason, Sarah L Booth

Open access · goldAbstract read
In one paragraph

Article in Gut microbes. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 74 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
74citing papers in PubMed, 3 pooled it
10.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

74 citing papers in PubMed, 3 syntheses or guidelines pooled it, 119 citations in OpenAlex.

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  13. Decoding the power of the microbiome in human health.Frontiers in cellular and infection microbiology · 2026
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14 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 6 institutions in 1 country.

Jessie L EllisJean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA, USA.
J Philip KarlMilitary Nutrition Division, US Army Research Institute of Environmental Medicine, Natick, MA, USA.
Angela M OliverioDepartment of Ecology and Evolutionary Biology, University of Colorado-Boulder, Boulder, CO, USA.
Xueyan FuJean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA, USA.
Jason W SoaresSoldier Effectiveness Directorate, US Army Combat Capabilities Developmental Command Soldier Center, Natick, MA, USA.
Benjamin E WolfeDepartment of Biology, Tufts University, Medford, MA, USA.
Christopher J HernandezSchools of Mechanical and Aerospace Engineering & Biomedical Engineering, Cornell University, Ithaca, NY, USA.
Joel B MasonJean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA, USA.
Sarah L BoothJean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA, USA.
Tufts University · USJean Mayer Human Nutrition Research Center on Aging · USCombat Capabilities Development Command Soldier Center · USCornell University · USUniversity of Colorado Boulder · USU.S. Army Research Institute of Environmental Medicine · US

Funding

Research Training Program in Nutrition, Obesity and Metabolic DisordersT32DK062032 · NIDDK · TUFTS UNIVERSITY BOSTON · PI GREENBERG, ANDREW S · 2002 to 2016
$2.6M
NIDDK NIH HHS T32 DK062032
6 · The paper itself

Abstract

Vitamins have well-established roles in bacterial metabolism. Menaquinones (MKn, n = prenyl units in sidechain) are bacterially produced forms of vitamin K produced by the gut microbiota and consumed in the diet. Little is known about the influence of dietary vitamin K quinones on gut microbial composition and MKn production. Here, male and female C57BL6 mice were fed a vitamin K deficient diet or vitamin K sufficient diets containing phylloquinone (PK, plant-based vitamin K form), MK4, and/or MK9. DNA was extracted from cecal contents and 16S sequencing conducted to assess microbial composition. Cecal microbial community composition was significantly different in vitamin K deficient female mice compared to females on vitamin K sufficient diets (all

Indexed as

Dietary SupplementsAdultAnimalsBacteriaBioreactorsCecumDietFecesFemaleFermentationGastrointestinal MicrobiomeHumansMaleMiceMice, Inbred C57BLMiddle AgedVitamin KVitamin K 2Vitamin K 3VitaminsGut microbiotamenaquinonemetabolismmicronutrientstable isotopevitamin K

Identifiers

PMID33651646
PMCPMC7928036
OpenAlexW3135350989

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.