Evidence map›Paper›PMID 33651602›Full record

ReviewChemical reviews2021

Click Chemistry with Cyclopentadiene.

Brian J Levandowski, Ronald T Raines

Abstract readReview
In one paragraph

Review in Chemical reviews, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Shape-Conserving Atom Replacements.Chemical reviews · 2026
    Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Taming the 1,5-sigmatropic shift across protonated spirocyclic 4Journal of physical organic chemistry · 2024
    Article
  11. Article
  12. Article
  13. Review
  14. Computational study of an oxetane 4Tetrahedron letters · 2023
    Article
  15. Dynamic Properties of Di(cyclopentadienecarboxylic Acid) Dimethyl Esters.International journal of molecular sciences · 2023
    Article
  16. Article
  17. Bioorthogonal 4Chemical communications (Cambridge, England) · 2023
    Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Brian J LevandowskiDepartment of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, United States.ORCID 0000-0002-8139-9417
Ronald T RainesDepartment of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, United States.ORCID 0000-0001-7164-1719

Funding

STRUCTURE--FUNCTION ANALYSIS OF RIBONUCLEASE AR01GM044783 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI RAINES, RONALD T · 1990 to 2021
$7.1M
Developing Cyclopentadiene as a Reagent in Bioorthogonal ChemistryF32GM137543 · NIGMS · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI LEVANDOWSKI, BRIAN · 2020 to 2022
$157k
NIGMS NIH HHS F32 GM137543NIGMS NIH HHS R01 GM044783
6 · The paper itself

Abstract

Cyclopentadiene is one of the most reactive dienes in normal electron-demand Diels-Alder reactions. The high reactivities and yields of cyclopentadiene cycloadditions make them ideal as click reactions. In this review, we discuss the history of the cyclopentadiene cycloaddition as well as applications of cyclopentadiene click reactions. Our emphasis is on experimental and theoretical studies on the reactivity and stability of cyclopentadiene and cyclopentadiene derivatives.

Indexed as

Click ChemistryCycloaddition ReactionCyclopentanesKineticsCyclopentanes

Identifiers

PMID33651602
PMCPMC8222071

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.