SynthesisJournal of thrombosis and haemostasis : JTH2021
Pediatric May-Thurner Syndrome-Systematic review and individual patient data meta-analysis.
Synthesis in Journal of thrombosis and haemostasis : JTH, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
8 citing papers in PubMed, 1 synthesis or guideline pooled it, 16 citations in OpenAlex.
- Clinical care of pediatric patients with or at risk of postthrombotic syndrome: guidance from the ISTH SSC Subcommittee on pediatric and neonatal thrombosis and hemostasis.Journal of thrombosis and haemostasis : JTH · 2024Guideline
- Evidence-Based Nursing Model in Interventional Thrombolysis for Acute Lower Extremity Arterial Embolism.Contrast media & molecular imaging · 2022Trial
- Deep vein thrombosis in a 14-year-old boy with a combination of May-Thurner syndrome, protein S deficiency and lupus anticoagulant: a case report.Journal of medical case reports · 2026Article
- Pediatric Venous Thromboembolism: Considerations for the Interventional Radiologist.Seminars in interventional radiology · 2025Review
- Venous anomalies: an underrecognized but important cause of venous thromboembolism.Blood vessels, thrombosis & hemostasis · 2024Article
- Familiar Disposition of May-Thurner Syndrome-A Case Series.Life (Basel, Switzerland) · 2024Article
- Article
- Case Report: Rare Iliac Vein Compression (May-Thurner) Syndrome in a Pediatric Patient.Frontiers in pediatrics · 2021Article
Corrections and comments
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Authors and funding
19 authors at 10 institutions in 4 countries.
Funding
Abstract
backgroundThe outcomes of deep vein thrombosis (DVT) in children with May-Thurner Syndrome (MTS) remain unclear.
objectivesThis systematic review and patient-level meta-analysis aims to describe the outcomes of children with MTS presenting with DVT.
methodsA systematic review of the published literature was performed. Data related to patients <18 years diagnosed with MTS and DVT was extracted. Risk of bias was assessed using the Murad criteria. Outcomes included vessel patency post-treatment, DVT recurrence, and post-thrombotic syndrome (PTS). Predictive and explanatory models were developed for these outcomes.
resultsIn total, 109 cases were identified (age range 4-17 years; 77 females) in 28 studies; 75% of patients had ≥1 additional risk factor for DVT. PTS was seen in 61% of patients, DVT recurrence in 38%, and complete vessel patency post-treatment in 65%. The models developed to predict and explain PTS performed poorly overall. Recurrent thrombosis (adjusted for age and patency) predicted PTS (odds ratio [OR] 3.36, 95% confidence interval [CI] 1.28-8.82). DVT management strategies (adjusted for age and DVT characteristics) predicted vessel patency (OR 2.10, 95% CI 1.43-3.08). Lack of complete vessel patency (adjusted for age and thrombophilia) predicted recurrent DVT (OR 2.70, 95% CI 1.09-6.67). Sensitivity analyses showed the same direction of effects for all outcomes.
conclusionsPTS and DVT recurrence occur frequently in pediatric MTS. PTS prediction is complex and it was not possible to identify early predictors to guide clinical practice. Use of imaging-guided therapy and thrombus burden predicted venous patency, and lack of patency predicted DVT recurrence.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.