Evidence map›Paper›PMID 33651387›Full record

ArticleJournal of internal medicine2021

Arterial stiffness in acute COVID-19 and potential associations with clinical outcome.

S Schnaubelt, J Oppenauer, D Tihanyi, M Mueller, E Maldonado-Gonzalez, S Zejnilovic, H Haslacher, T Perkmann, R Strassl, S Anders and 5 more

Open access · hybridAbstract read
In one paragraph

Article in Journal of internal medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 60 papers.

0numbers the graph read from it
0cells of the map it votes in
60citing papers in PubMed
12.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

60 citing papers in PubMed, 96 citations in OpenAlex.

  1. The effect of an mRNA vaccine against COVID-19 on endothelial function and arterial stiffness.Hypertension research : official journal of the Japanese Society of Hypertension · 2022
    Trial
  2. Review
  3. Article
  4. Article
  5. Article
  6. Observational
  7. Article
  8. Article
  9. Article
  10. Article
  11. Observational
  12. Article
  13. Article
  14. Review
  15. Article
  16. Article
  17. Article
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 3 institutions in 1 country.

S SchnaubeltFrom the, Department of Emergency Medicine, Medical University of Vienna, Vienna, Austria.ORCID https://orcid.org/0000-0003-0057-8200
J OppenauerFrom the, Department of Emergency Medicine, Medical University of Vienna, Vienna, Austria.
D TihanyiDepartment of Pulmonology, Clinic Penzing, Vienna Health Care Group, Vienna, Austria.
M MuellerDivision of Angiology, Department of Medicine II, Medical University of Vienna, Vienna, Austria.
E Maldonado-GonzalezDepartment of Medicine I, Clinic Donaustadt, Vienna Health Care Group, Vienna, Austria.
S ZejnilovicFrom the, Department of Emergency Medicine, Medical University of Vienna, Vienna, Austria.
H HaslacherDepartment of Laboratory Medicine, Medical University of Vienna, Vienna, Austria.
T PerkmannDepartment of Laboratory Medicine, Medical University of Vienna, Vienna, Austria.
R StrasslDivision of Clinical Virology, Department of Laboratory Medicine, Medical University of Vienna, Vienna, Austria.
S AndersDepartment of Pulmonology, Clinic Penzing, Vienna Health Care Group, Vienna, Austria.
T StefenelliDepartment of Medicine I, Clinic Donaustadt, Vienna Health Care Group, Vienna, Austria.
S ZehetmayerCentre for Medical Statistics, Information Technology and Intelligent Systems, Medical University of Vienna, Vienna, Austria.
R KoppensteinerDivision of Angiology, Department of Medicine II, Medical University of Vienna, Vienna, Austria.
H DomanovitsFrom the, Department of Emergency Medicine, Medical University of Vienna, Vienna, Austria.
O SchlagerDivision of Angiology, Department of Medicine II, Medical University of Vienna, Vienna, Austria.
Medical University of Vienna · ATDonauspital · ATStatistics Austria · AT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundCoronavirus disease 2019 (COVID-19) interferes with the vascular endothelium. It is not known whether COVID-19 additionally affects arterial stiffness.

methodsThis case-control study compared brachial-ankle pulse wave (baPWV) and carotid-femoral pulse wave velocities (cfPWV) of acutely ill patients with and without COVID-19.

resultsTwenty-two COVID-19 patients (50% females, 77 [67-84] years) were compared with 22 age- and sex-matched controls. In COVID-19 patients, baPWV (19.9 [18.4-21.0] vs. 16.0 [14.2-20.4], P = 0.02) and cfPWV (14.3 [13.4-16.0] vs. 11.0 [9.5-14.6], P = 0.01) were higher than in the controls. In multiple regression analysis, COVID-19 was independently associated with higher cfPWV (β = 3.164, P = 0.004) and baPWV (β = 3.532, P = 0.003). PWV values were higher in nonsurvivors. In survivors, PWV correlated with length of hospital stay.

conclusionCOVID-19 appears to be related to an enhanced PWV reflecting an increase in arterial stiffness. Higher PWV might be related to an increased length of hospital stay and mortality.

Indexed as

AgedAged, 80 and overBrachial ArteryCarotid ArteriesCase-Control StudiesCOVID-19FemaleFemoral ArteryHumansLength of StayMalePulse Wave AnalysisSurvivorsVascular Stiffnessarterial stiffnesscardiovascular riskCOVID-19pulse wave velocitySARS-CoV-2

Identifiers

PMID33651387
PMCPMC8013324
OpenAlexW3135495170

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.