SynthesisEndocrine2021
What are the real rates of temporary hypoparathyroidism following thyroidectomy? It is a matter of definition: a systematic review.
Synthesis in Endocrine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
29 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The outcomes of parathyroid gland autotransplantation during thyroid surgery: a systematic review, meta-analysis and trial sequential analysis.Endocrine · 2025Pooled it
- Impact of autofluorescence for detection of parathyroid glands during thyroidectomy on postoperative parathyroid hormone levels: parallel multicentre randomized clinical trial.The British journal of surgery · 2023Trial
- Italian guidelines for the management of adult individuals with post-surgical hypoparathyroidism.Journal of endocrinological investigation · 2026Article
- Does parathyroid autofluorescence reduces unintentional parathyroidectomy during total thyroidectomy with central lymph node compartment dissection?Updates in surgery · 2026Article
- Early Detection of Transient Hypoparathyroidism After Total Thyroidectomy: A Single-Center Preliminary Study.Medicina (Kaunas, Lithuania) · 2026Article
- Clinical manifestations of injured tracheal and esophageal branches of the recurrent laryngeal nerve following thyroid surgery.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2026Article
- Calculation of postoperative parathyroid hormone level using indocyanine green angiography during robotic total thyroidectomy: equivalent function hypothesis.Surgical endoscopy · 2026Article
- Preoperative Lugol's solution and surgical outcomes in Graves' disease: a single-center retrospective study.Frontiers in surgery · 2026Article
- Developing a surgical trial intervention protocol: using qualitative methods in the operating theatre.Trials · 2025Article
- Article
- An outcome analysis of utilizing contrast-free near-infrared autofluorescence imaging in thyroid cancer surgery: a retrospective study.Updates in surgery · 2025Article
- Development and validation of risk prediction models for permanent hypocalcemia after total thyroidectomy in patients with papillary thyroid carcinoma.Scientific reports · 2025Article
- Impact of thyroid volume on serum ionized calcium and PTH levels after total thyroidectomy.Sao Paulo medical journal = Revista paulista de medicina · 2025Observational
- Fluorescence intensity of parathyroid glands in thyroid and parathyroid surgery: a near-infrared autofluorescence study.Frontiers in surgery · 2025Article
- An automatic parathyroid recognition and segmentation model based on deep learning of near-infrared autofluorescence imaging.Cancer medicine · 2024Article
- Active surveillance versus immediate surgery in the management of low-risk papillary thyroid microcarcinoma: comparison of long-term costs in Brazil.Archives of endocrinology and metabolism · 2024Article
- Serum PTH at 4 h after total thyroidectomy as a predictor of hypocalcemia: a prospective time frame analysis in search of evidence.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2023Article
- Risk Factors for Hypoparathyroidism after Thyroid Surgery: A Single-Center Study.Journal of clinical medicine · 2023Article
- Lobectomy and completion thyroidectomy rates increase after the 2015 American Thyroid Association Differentiated Thyroid Cancer Guidelines update.Endocrine oncology (Bristol, England) · 2023Article
- Indocyanine green angiography-guided thyroidectomy versus conventional thyroidectomy for preserving parathyroid function: study protocol for a randomized single-blind controlled trial.Frontiers in endocrinology · 2023Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionPost-operative hypoparathyroidism is the most encountered complication of thyroid surgery and is classified as temporary or permanent. However, its incidence varies greatly in the literature ranging from 0.5% to 65%. This can be mainly attributed to the different definition of hypoparathyroidism used in each study and especially to the different time cutoff applied to distinguish temporary from permanent hypoparathyroidism.
methodsWe conducted a systematic literature search in PubMed, Scopus, Cochrane and GoogleScholar databases, as well as grey literature. Ultimately, 45 articles with 23,164 patients in total were included in this review. These articles used either the cutoff of six or twelve post-operative months to distinguish temporary from permanent hypoparathyroidism.
resultsThe overall incidence of permanent hypoparathyroidism diagnosed at 6 months post-operatively was 4.11% and 4.08% at 12 months post-operatively. There was no statistically significant difference between the two groups (p = 0.92).
conclusionsWe suggest that adhering to the current guidelines that recommend diagnosing temporary hypoparathyroidism when recovery is made within 6 months after surgery is important when conducting future research in order to narrow the gap that exists currently in the literature, as well as when deciding to put patients on long-term calcium supplements.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.