ArticleClinical oral investigations2021
Odontogenesis-related candidate genes involved in variations of permanent teeth size.
Article in Clinical oral investigations, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 15 citations in OpenAlex.
- Association between single-nucleotide polymorphisms in endochondral development-related genes and 3D phenotypic variation of the cranial base.Head & face medicine · 2026Article
- Polymorphisms and dental age in non-syndromic cleft lip and palate: a cross-sectional study.BMC pediatrics · 2025Article
- Exploring polymorphisms in genes encoding growth factors associated with non-syndromic cleft lip with or without cleft palate and tooth agenesis.Journal of applied oral science : revista FOB · 2025Article
- Mandibular and dental measurements for sex determination using machine learning.Scientific reports · 2024Article
- BMP2 rs1005464 is associated with mandibular condyle size variation.Scientific reports · 2024Article
- Single Nucleotide Polymorphisms in RUNX2 and BMP2 contributes to different vertical facial profile.PloS one · 2024Article
- Developmental enamel defects and dental anomalies of number and size in children with growth hormone deficiency.Scientific reports · 2023Article
- Impact of FokI (rs2228570) and BglI (rs739837) polymorphisms inJournal of oral biology and craniofacial researchArticle
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Authors and funding
9 authors at 4 institutions in 2 countries.
Funding
Abstract
objectiveThe aim of the study was to evaluate the association between genetic polymorphisms in RUNX2, BMP4, BMP2, TGFβ1, EGF, and SMAD6 and variations in permanent tooth size (TS). MATERIALS AND
methodsThis cross-sectional study evaluated 110 individuals' dental casts to determine the maximum tooth crown size of all fully erupted permanent teeth (third molars were excluded) in the mesiodistal (MD) and buccolingual (BL) dimensions. Genomic DNA was obtained from the epithelial cells of the oral mucosa to evaluate the genetic polymorphisms in RUNX2 (rs59983488 and rs1200425), BMP4 (rs17563), BMP2 (rs235768 and rs1005464), TGFβ1 (rs1800470), EGF (rs4444903), and SMAD6 (rs2119261 and rs3934908) through real-time PCR. The data were submitted to statistical analysis with a significance level of 0.05.
resultsThe genetic polymorphisms rs59983488, rs1200425, rs17563, rs235768, rs1005464, rs1800470, and rs4444903 were associated with MD and BL TS of the upper and lower arches (p < 0.05). The polymorphism rs2119261 was associated with variation in TS only in the upper arch (p < 0.05). The rs3934908 was not associated with any TS measurement (p > 0.05).
conclusionsIn summary, this study reports novel associations between variation in permanent TS and genetic polymorphisms in RUNX2, BMP4, BMP2, TGFβ1, EGF, and SMAD6 indicating a possible role of these genes in dental morphology. CLINICAL RELEVANCE: Polymorphisms in odontogenesis-related genes may be involved in dental morphology enabling a prediction of permanent TS variability. The knowledge regarding genes involved in TS might impact the personalized dental treatment, considering that patients' genetic profile would soon be introduced into clinical practice to improve patient management.
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