Evidence map›Paper›PMID 33651206›Full record

ArticleBiomechanics and modeling in mechanobiology2021

Mechanics informed fluoroscopy of esophageal transport.

Sourav Halder, Shashank Acharya, Wenjun Kou, Peter J Kahrilas, John E Pandolfino, Neelesh A Patankar

Registry-linked trialOpen access · greenAbstract read
In one paragraph

Article in Biomechanics and modeling in mechanobiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06883175 (Evolution of the Chicago Classification), which is not on this map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
2.9field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06883175 narecruitingnot on this mapstarted 2024, after this paper: background citation

Evolution of the Chicago Classification: Bridging Physiology and Mechanics

TypeinterventionalSponsorNorthwestern UniversityRan2024 to 2029Enrolled575ConditionsDysphagia, Achalasia, Esophageal, Ineffective Esophageal MotilityArmsFLIP, HRM, Prucalopride
3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 17 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Oesophageal fluoroscopy in adults-when and why?The British journal of radiology · 2024
    Review
  7. Article
  8. Article
  9. Article
  10. Review
  11. Peristaltic regimes in esophageal transport.Biomechanics and modeling in mechanobiology · 2023
    Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Assessment of esophageal body peristaltic work using functional lumen imaging probe panometry.American journal of physiology. Gastrointestinal and liver physiology · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Sourav HalderTheoretical and Applied Mechanics, Northwestern University, 2145 Sheridan Road, Evanston, IL, 60208, USA.ORCID http://orcid.org/0000-0002-8366-8860
Shashank AcharyaDepartment of Mechanical Engineering, Northwestern University, 2145 Sheridan Road, Evanston, IL, 60208, USA.ORCID http://orcid.org/0000-0001-5341-1792
Wenjun KouDepartment of Medicine, Feinberg School of Medicine, Northwestern University, 676 North Saint Clair St., Chicago, IL, 60611, USA.
Peter J KahrilasDepartment of Medicine, Feinberg School of Medicine, Northwestern University, 676 North Saint Clair St., Chicago, IL, 60611, USA.
John E PandolfinoDepartment of Medicine, Feinberg School of Medicine, Northwestern University, 676 North Saint Clair St., Chicago, IL, 60611, USA.
Neelesh A PatankarTheoretical and Applied Mechanics, Northwestern University, 2145 Sheridan Road, Evanston, IL, 60208, USA. n-patankar@northwestern.edu.ORCID http://orcid.org/0000-0002-0665-3454
Northwestern University · US

Funding

Northwestern University Clinical and Translational Science Institute (NUCATS)UL1TR001422 · NCATS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI D'AQUILA, RICHARD · 2015 to 2023
$56.8M
Role of altered response to volumetric distension in esophageal diseaseP01DK117824 · NIDDK · NORTHWESTERN UNIVERSITY AT CHICAGO · PI PANDOLFINO, JOHN E · 2018 to 2022
$7.3M
The mechanics of symptom generation in dysphagiaR01DK079902 · NIDDK · NORTHWESTERN UNIVERSITY AT CHICAGO · PI PANDOLFINO, JOHN E · 2009 to 2017
$2.9M
National Science Foundation OAC 1450374National Science Foundation OAC 1931372NCATS NIH HHS UL1 TR001422NIDDK NIH HHS P01 DK117824NIDDK NIH HHS P01-DK117824NIDDK NIH HHS R01 DK079902NIDDK NIH HHS R01-DK079902
6 · The paper itself

Abstract

Fluoroscopy is a radiographic procedure for evaluating esophageal disorders such as achalasia, dysphasia and gastroesophageal reflux disease. It performs dynamic imaging of the swallowing process and provides anatomical detail and a qualitative idea of how well swallowed fluid is transported through the esophagus. In this work, we present a method called mechanics informed fluoroscopy (FluoroMech) that derives patient-specific quantitative information about esophageal function. FluoroMech uses a convolutional neural network to perform segmentation of image sequences generated from the fluoroscopy, and the segmented images become input to a one-dimensional model that predicts the flow rate and pressure distribution in fluid transported through the esophagus. We have extended this model to identify and estimate potential physiomarkers such as esophageal wall stiffness and active relaxation ahead of the peristaltic wave in the esophageal musculature. FluoroMech requires minimal computational time and hence can potentially be applied clinically in the diagnosis of esophageal disorders.

Indexed as

FluoroscopyBiological TransportBiomechanical PhenomenaEsophagusHumansImage Processing, Computer-AssistedNeural Networks, ComputerPressureConvolutional neural networkEsophageal active relaxationEsophageal wall stiffnessFlexible tubeImage segmentationOne-dimensional flow

Identifiers

PMID33651206
PMCPMC8159889
OpenAlexW3081179461

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.