Evidence map›Paper›PMID 33651154›Full record

ArticleJournal of neurology2021

5-Year health-related quality of life outcome in patients with idiopathic normal pressure hydrocephalus.

A Junkkari, H Sintonen, N Danner, H K Jyrkkänen, T Rauramaa, A J Luikku, A M Koivisto, R P Roine, H Viinamäki, H Soininen and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of neurology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
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  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

A JunkkariNeurosurgery of NeuroCenter, Kuopio University Hospital and University of Eastern Finland, 70029 KYS, POB 100, Kuopio, Finland. antti.junkkari@kuh.fi.ORCID http://orcid.org/0000-0001-8715-1749
H SintonenDepartment of Public Health, University of Helsinki, Helsinki, Finland.ORCID http://orcid.org/0000-0003-1252-0946
N DannerNeurosurgery of NeuroCenter, Kuopio University Hospital and University of Eastern Finland, 70029 KYS, POB 100, Kuopio, Finland.ORCID http://orcid.org/0000-0002-7094-4432
H K JyrkkänenNeurosurgery of NeuroCenter, Kuopio University Hospital and University of Eastern Finland, 70029 KYS, POB 100, Kuopio, Finland.
T RauramaaDepartment of Pathology, Kuopio University Hospital and University of Eastern Finland, Kuopio, Finland.ORCID http://orcid.org/0000-0002-2250-327X
A J LuikkuNeurosurgery of NeuroCenter, Kuopio University Hospital and University of Eastern Finland, 70029 KYS, POB 100, Kuopio, Finland.ORCID http://orcid.org/0000-0003-2864-1953
A M KoivistoDepartment of Neurology, University of Eastern Finland, Kuopio, Finland.
R P RoineDepartment of Health and Social Management, University of Eastern Finland, Kuopio, Finland.
H ViinamäkiDepartment of Psychiatry, Kuopio University Hospital and University of Eastern Finland, Kuopio, Finland.
H SoininenDepartment of Neurology, University of Eastern Finland, Kuopio, Finland.ORCID http://orcid.org/0000-0002-2785-9937
J E JääskeläinenNeurosurgery of NeuroCenter, Kuopio University Hospital and University of Eastern Finland, 70029 KYS, POB 100, Kuopio, Finland.
V LeinonenNeurosurgery of NeuroCenter, Kuopio University Hospital and University of Eastern Finland, 70029 KYS, POB 100, Kuopio, Finland.ORCID http://orcid.org/0000-0002-4282-4687

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundHealth-related quality of life (HRQoL) is severely impaired in persons with idiopathic normal pressure hydrocephalus (iNPH). The HRQoL improves in a number of patients after the placement of a cerebrospinal fluid (CSF) shunt, but long-term follow-up of HRQoL is rare.

methodsExtended follow-up (60 months) of a prospective cohort study involving 189 patients with iNPH who underwent shunt surgery. Preoperative variables were used to predict favorable HRQoL outcome (improvement or non-deterioration) measured by the 15D instrument 5 years after shunting.

resultsOut of the 189 initially enrolled study participants, 88 had completed 5-year HRQoL follow-up (46%), 64 had died (34%), and 37 (20%) failed to complete the HRQoL follow-up but were alive at the end of the study. After initial post-operative HRQoL improvement, HRQoL deteriorated so that 37/88 participants (42%) had a favorable HRQoL outcome 5 years after shunting. Multivariate binary logistic regression analysis indicated that younger age (adjusted OR 0.86, 95% CI 0.77-0.95; p < 0.005), lower body mass index (adjusted OR 0.87, 95% CI 0.77-0.98; p < 0.05) and better Mini-Mental State Examination performance (adjusted OR 1.16, 95% CI 1.01-1.32; p < 0.05) before surgery predicted favorable 5-year outcome.

conclusionsThis extended follow-up showed that the self-evaluated HRQoL outcome is associated with iNPH patients' pre-operative cognitive status, overweight and age. The post-operative deterioration may reflect the natural progression of iNPH, but also derive from aging and comorbidities. It indicates a need for long-term follow-up.

Indexed as

Hydrocephalus, Normal PressureQuality of LifeCerebrospinal Fluid ShuntsHumansProspective StudiesTreatment Outcome15DCharlson Age Comorbidity IndexComorbidityFrontal cortical biopsyHealth-related quality of lifeIdiopathic normal pressure hydrocephalus

Identifiers

PMID33651154
PMCPMC8357651

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.