ArticleApplied microbiology and biotechnology2021
Characterization of a Bacillus megaterium strain with metal bioremediation potential and in silico discovery of novel cadmium binding motifs in the regulator, CadC.
Article in Applied microbiology and biotechnology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Molecular basis of heavy metal tolerance in the marine actinomycete Nocardiopsis dassonvillei NCIM 5124.World journal of microbiology & biotechnology · 2026Article
- Lactiplantibacillus from Peruvian Criollo Blanco Cocoa and Cadmium Removal via a Bacterial Consortium During Cocoa Fermentation.Current microbiology · 2025Article
- A Portable Arsenic Sensor IntegratingACS synthetic biology · 2025Article
- Elucidation of the CadA Protein 3D Structure and Affinity for Metals.Bioinformatics and biology insights · 2024Article
- Plant growth-promoting and heavy metal-resistant Priestia and Bacillus strains associated with pioneer plants from mine tailings.Archives of microbiology · 2023Article
- Reduced Antibiotic Resistance in the Rhizosphere ofBiology · 2023Article
- Bacillus megaterium HgT21: a Promising Metal Multiresistant Plant Growth-Promoting Bacteria for Soil Biorestoration.Microbiology spectrum · 2022Article
- Microbial whole-cell biosensors: Current applications, challenges, and future perspectives.Biosensors & bioelectronics · 2021Review
- Unraveling the Underlying Heavy Metal Detoxification Mechanisms ofMicroorganisms · 2021Review
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Bioremediation of toxic metal ions using bacterial strains is a promising tool. Metal binding motifs in microbial proteins are involved in the regulation and transport of such toxic metals for metal detoxification. A bacterial strain designated TWSL_4 with metal (Cu, Cd, and Pb) resistance and removal ability was isolated and identified as a Bacillus megaterium strain using 16S rRNA gene analysis. An operon with 2 open reading frames (ORFs) was identified, cloned, and sequenced. ORF1 and ORF2 were identical to the cadmium efflux system accessory protein (CadC) and cadmium-translocating P-type ATPases (CadA) of B. megaterium strain YC4-R4 respectively. A protein homology search using Swiss model retrieved no crystal structures for CadC and CadA of Bacillus sp.. CadC of TWSL_4 had a sequence identity of 53% to the CadC (121aa) protein and 51.69% to the CadC crystal structure (1U2W.1.B; GMQE=0.75) of Staphylococcus sp. pI258. Molecular dynamic simulation studies revealed the presence of three metal binding regions in CadC of TWSL_4, [ASP7-TYR9], [ASP100-HIS102], and [LYS113-ASP116]. This is the first report showing evidence for the presence of Cd
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