Evidence map›Paper›PMID 33651116›Full record

ArticleEuropean journal of nuclear medicine and molecular imaging2021

Phase I study to assess safety, biodistribution and radiation dosimetry for

Robin I J Merkx, Daphne Lobeek, Mark Konijnenberg, Luis David Jiménez-Franco, Andreas Kluge, Egbert Oosterwijk, Peter F A Mulders, Mark Rijpkema

Registry-linked trialOpen access · hybridAbstract readClinical Trial, Phase I
In one paragraph

Article in European journal of nuclear medicine and molecular imaging, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03556046 (An Open-label, Phase I Study to Assess Safety, Tolerability, Radiation Dosimetry, and Imaging Properties of 89Zr-labelled Girentuximab), which is not on this map. Cited by 50 papers.

0numbers the graph read from it
0cells of the map it votes in
50citing papers in PubMed
6.9field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03556046 phase1completednot on this map

An Open-label, Phase I Study to Assess Safety, Tolerability, Radiation Dosimetry, and Imaging Properties of 89Zr-labelled Girentuximab (89Zr-girentuximab) for in Vivo Detection of Clear Cell Renal Carcinoma (CCRC) by Positron Emission Tomography (PET) Using Different PET Imaging Methodologies

TypeinterventionalSponsorRadboud University Medical CenterRan2018 to 2018Enrolled10ConditionsClear Cell Renal CarcinomaArms89Zr-Girentuximab
3 · Its place in the literature

Who cites it

50 citing papers in PubMed, 66 citations in OpenAlex.

  1. Trial
  2. Prospective pilot study with [European journal of nuclear medicine and molecular imaging · 2026
    Trial
  3. First-in-human dosimetry and biodistribution of [European journal of nuclear medicine and molecular imaging · 2026
    Article
  4. Predicting tumour and organ dose in α-radiopharmaceutical therapy: aEuropean journal of nuclear medicine and molecular imaging · 2026
    Article
  5. Occult metastases detection and impact on management in renal cell carcinoma imaged with [European journal of nuclear medicine and molecular imaging · 2026
    Article
  6. Review
  7. Article
  8. Review
  9. Review
  10. Review
  11. Article
  12. A Bioimaging Study ofMolecular imaging and biology · 2026
    Article
  13. Review
  14. Carbonic Anhydrase Inhibitors in Oncology.Sub-cellular biochemistry · 2026
    Review
  15. Article
  16. Evaluation of [EJNMMI research · 2025
    Article
  17. Article
  18. Targeting Extra Domain A of Fibronectin to Improve Noninvasive Detection of Triple-Negative Breast Cancer.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2025
    Article
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Robin I J MerkxDepartment of Medical Imaging: Nuclear Medicine, Radboudumc, Geert Grooteplein Zuid 10, 6525 GA, Nijmegen, The Netherlands. Robin.Merkx@radboudumc.nl.ORCID 0000-0002-0846-6775
Daphne LobeekDepartment of Medical Imaging: Nuclear Medicine, Radboudumc, Geert Grooteplein Zuid 10, 6525 GA, Nijmegen, The Netherlands.
Mark KonijnenbergDepartment of Medical Imaging: Nuclear Medicine, Radboudumc, Geert Grooteplein Zuid 10, 6525 GA, Nijmegen, The Netherlands.
Luis David Jiménez-FrancoABX-CRO advanced pharmaceutical services, Dresden, Germany.
Andreas KlugeABX-CRO advanced pharmaceutical services, Dresden, Germany.
Egbert OosterwijkDepartment of Urology, Radboudumc, Nijmegen, The Netherlands.
Peter F A MuldersDepartment of Urology, Radboudumc, Nijmegen, The Netherlands.
Mark RijpkemaDepartment of Medical Imaging: Nuclear Medicine, Radboudumc, Geert Grooteplein Zuid 10, 6525 GA, Nijmegen, The Netherlands.
Radboud University Nijmegen · NLABX-CRO Advanced Pharmaceutical Services (Germany) · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeIn this phase I study, we evaluated the safety, biodistribution and dosimetry of [

methodsTen eligible patients received an intravenous administration of 37 MBq (± 10%) of

results

conclusionsThis study demonstrates that

trial registrationNCT03556046-14th of June, 2018.

Indexed as

Carcinoma, Renal CellKidney NeoplasmsAntibodies, MonoclonalHumansPositron-Emission TomographyPositron Emission Tomography Computed TomographyRadiometryTissue Distribution(89)Zr-girentuximabAntibodies, MonoclonalG250 monoclonal antibodyGirentuximabOrgan-based dosimetryRCCZirconium-89

Identifiers

PMID33651116
PMCPMC8426244
OpenAlexW3133643670

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.