ArticlePhysiological reports2021
Achieving sustained extrauterine life: Challenges of an artificial placenta in fetal pigs as a model of the preterm human fetus.
Article in Physiological reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 41 citations in OpenAlex.
- Influence of arteries, vein and placenta interactions on the blood flow in the human umbilical cord.PloS one · 2026Article
- Review
- Reperfused human umbilical cords: hydrodynamic and hemolytic analysis of theFrontiers in bioengineering and biotechnology · 2026Article
- Artificial Womb Technology for Extremely Premature Neonates: Preclinical Neurodevelopmental Outcomes.Children (Basel, Switzerland) · 2025Review
- Defining the threshold of birth: ethical introduction of artificial placenta and artificial womb technology in the neonatal intensive care unit.Journal of perinatology : official journal of the California Perinatal Association · 2025Review
- Dietary Glyceryl Monolaurate Supplementation During Pregnancy Enhances Fetal Intrauterine Development and Antioxidant Capacity in Sows via Microbiota Modulation.Antioxidants (Basel, Switzerland) · 2025Article
- Artificial womb technology - A more physiologic solution to treating extreme prematurity.European journal of obstetrics & gynecology and reproductive biology: X · 2025Review
- Article
- Reperfused human umbilical cords as anFrontiers in bioengineering and biotechnology · 2025Article
- Transferring an extremely premature infant to an extra-uterine life support system: a prospective view on the obstetric procedure.Frontiers in pediatrics · 2024Review
- Ethical challenges in first-in-human trials of the artificial placenta and artificial womb: not all technologies are created equally, ethically.Journal of perinatology : official journal of the California Perinatal Association · 2023Review
- Article
- Article
- Artificial placenta support of extremely preterm ovine fetuses at the border of viability for up to 336 hours with maintenance of systemic circulation but reduced somatic and organ growth.Frontiers in physiology · 2023Article
- Advanced imaging of fetal cardiac function.Frontiers in cardiovascular medicine · 2023Review
- Ethical, Translational, and Legal Issues Surrounding the Novel Adoption of Ectogestative Technologies.Risk management and healthcare policy · 2022Review
- Impact of the Addition of a Centrifugal Pump in a Preterm Miniature Pig Model of the Artificial Placenta.Frontiers in physiology · 2022Article
- Achieving sustained extrauterine life: Challenges of an artificial placenta in fetal pigs as a model of the preterm human fetus.Physiological reports · 2021Article
Corrections and comments
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Authors and funding
23 authors at 3 institutions in 2 countries.
Funding
Abstract
Artificial placenta (AP) technology aims to maintain fetal circulation, while promoting the physiologic development of organs. Recent reports of experiments performed in sheep indicate the intrauterine environment can be recreated through the cannulation of umbilical vessels, replacement of the placenta with a low-resistance membrane oxygenator, and incubation of the fetus in fluid. However, it remains to be seen whether animal fetuses similar in size to the extremely preterm human infant that have been proposed as a potential target for this technology can be supported in this way. Preterm Yucatan miniature piglets are similar in size to extremely preterm human infants and share similar umbilical cord anatomy, raising the possibility to serve as a good model to investigate the AP. To characterize fetal cardiovascular physiology, the carotid artery (n = 24) was cannulated in utero and umbilical vein (UV) and umbilical artery were sampled. Fetal UV flow was measured by MRI (n = 16). Piglets were delivered at 98 ± 4 days gestation (term = 115 days), cannulated, and supported on the AP (n = 12) for 684 ± 228 min (range 195-3077 min). UV flow was subphysiologic (p = .002), while heart rate was elevated on the AP compared with in utero controls (p = .0007). We observed an inverse relationship between heart rate and UV flow (r
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.