Trial reportClinical and translational science2021
Effect of selenium on thyroid autoimmunity and regulatory T cells in patients with Hashimoto's thyroiditis: A prospective randomized-controlled trial.
Trial report in Clinical and translational science, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
55 citing papers in PubMed, 2 syntheses or guidelines pooled it, 85 citations in OpenAlex.
- Selenium Supplementation in Patients with Hashimoto Thyroiditis: A Systematic Review and Meta-Analysis of Randomized Clinical Trials.Thyroid : official journal of the American Thyroid Association · 2024Pooled it
- Effects of different supplements on Hashimoto's thyroiditis: a systematic review and network meta-analysis.Frontiers in endocrinology · 2024Pooled it
- Correlation between thyroid hormone levels and cognitive dysfunction in older patients with subclinical hypothyroidism : A matched groups retrospective study.Wiener klinische Wochenschrift · 2026Article
- Association Between Dietary Anthocyanidin Intake and Thyroid Autoimmunity: A Cross-Sectional Study From NHANES (2007-2010).Health science reports · 2026Article
- Clinical and Biochemical Predictors of Thyroid Autoantibody Levels in Hashimoto's Thyroiditis.Cureus · 2026Article
- Preventive and Ameliorative Effects of Se- and Zn-Biofortified Chickpeas on MAFLD-Related Metabolic Disturbances.Foods (Basel, Switzerland) · 2026Article
- Article
- Clinical Outcomes of Selenium Supplementation in Hashimoto's Thyroiditis Without Selenium Deficiency: A Large-Scale Retrospective Cohort Study.Endocrinology, diabetes & metabolism · 2026Article
- Systemic inflammatory markers predict mortality in autoimmune thyroiditis: threshold-driven risk stratification and prognostic insights from a nationwide cohort.Hormones (Athens, Greece) · 2026Article
- The caprices of a trace element: selenium's considerable effects on Hashimoto's thyroiditis, though few on Graves' disease.European thyroid journal · 2026Review
- Hashimoto's thyroiditis both promotes and protects against papillary thyroid cancer.Frontiers in endocrinology · 2026Review
- Heterozygous pathogenic variants inOpen life sciences · 2026Article
- Hashimoto's thyroiditis: from pathogenesis to clinical management.Frontiers in endocrinology · 2026Review
- Immunopathogenesis, Diagnosis, and Treatment of Hashimoto's Thyroiditis.Archives of internal medicine research · 2026Article
- The Impact of Selenium Deficiency and Supplementation on Hashimoto's Thyroiditis: A Clinical Evaluation.Endocrine, metabolic & immune disorders drug targets · 2026Article
- Selenium-enrichedFrontiers in fungal biology · 2026Article
- Shared Immunopathogenic Mechanisms in Chronic Spontaneous Urticaria, Vitiligo, and Hashimoto's Thyroiditis: The Role of Oxidative Stress and Vitamin D.Life (Basel, Switzerland) · 2025Review
- Thyroid Health and Selenium: The Critical Role of Adequate Intake from Fetal Development to Adolescence.Nutrients · 2025Review
- Current literature support and opposition for therapeutic use of selenium supplementation in autoimmune thyroid conditions.Biochemistry and biophysics reports · 2025Review
- Immunomodulatory Effects of Selected Non-Nutritive Bioactive Compounds and Their Role in Optimal Nutrition.Current issues in molecular biology · 2025Review
Corrections and comments
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Authors and funding
11 authors at 2 institutions in 1 country.
Funding
Abstract
Selenium (Se) is an essential trace element in human. Recent studies of Se supplementation on the effect of Hashimoto's thyroiditis (HT) have been reported, but the exact benefit is unclear as well as the underlying immunologic mechanism. We aimed to evaluate the clinical effect of Se supplement in patients with HT, and explore the potential mechanism against thyroid autoimmunity. A prospective, randomized-controlled study was performed in patients with HT assigned to two groups. Se-treated group (n = 43) received selenious yeast tablet (SYT) for 6 months, whereas no treatment in control group (n = 47). The primary outcome is the change of thyroid peroxidase antibody (TPOAb) or thyroglobulin antibody (TGAb). Second, thyroid function, urinary iodine, Se, Glutathione peroxidase3 (GPx3), and Selenoprotein P1 (SePP1) levels were measured during the SYT treatment. Meanwhile, regulatory T cells (Tregs) and their subsets activated Tregs (aTregs), resting Tregs, and secreting Tregs, as well as Helios and PD-1 expression on these cells were also detected. The results showed that SYT treatment significantly decreased TPOAb, TGAb, and thyroid stimulating hormone (TSH) levels, accompanied with the increased Se, GPx3, and SePP1, compared with the control group. Subgroup analysis revealed that subclinical HT may benefit more from this treatment in the decrease of TSH levels by interaction test. Moreover, the percentage of aTregs, Helios/Tregs, and Helios/aTregs were significantly higher in the Se-treated group than control. In conclusion, Se supplementation may have a beneficial effect on thyroid autoantibodies and thyroid function by increasing the antioxidant activity and upregulating the activated Treg cells.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.