SynthesisArthritis care & research2022
Examining the Relationship Between Rheumatoid Arthritis, Multimorbidity, and Adverse Health-Related Outcomes: A Systematic Review.
Synthesis in Arthritis care & research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
21 citing papers in PubMed.
- Weekly Walking Attenuates the Association Between Frailty and Depressive Symptoms in Patients With Rheumatoid Arthritis.Research in nursing & health · 2026Observational
- Disparities in clinical characteristics and health-related quality of life among young, young-onset elderly and elderly-onset rheumatoid arthritis patients: A large-scale national survey.Clinical rheumatology · 2026Article
- The Impact of Comorbidities on Health-Related Quality of Life Among Patients with Rheumatoid Arthritis.Healthcare (Basel, Switzerland) · 2026Article
- MCCs in adults with autoimmune and inflammatory rheumatic diseases: evidence to date and future directions.Therapeutic advances in musculoskeletal disease · 2026Review
- Eye-openers for advanced management of elderly-onset rheumatoid arthritis.Rheumatology (Oxford, England) · 2025Article
- From autoimmune inflammation to malignancy: causal genetic evidence for the RA-squamous cell lung cancer axis.Arthritis research & therapy · 2025Article
- From Multimorbidity to Network Medicine in Patients with Rheumatic Diseases.Rheumatology and therapy · 2025Review
- A Cross-Sectional Study of Quality of Life, Treatment Adherence, and Health-Seeking Behavior in Turkish Patients with Rheumatoid Arthritis: Gender and Education as Key Predictors.Patient preference and adherence · 2025Article
- Prevalence of comorbidities among patients with rheumatoid arthritis in the UAE: a case-control study.BMJ open · 2024Article
- Sex Differences in Cardiovascular Risk Profiles of Patients with Rheumatoid Arthritis: Results from an Italian Multicentre Cohort.Journal of clinical medicine · 2024Article
- Disparities in multimorbidity and comorbidities in rheumatoid arthritis by sex across the lifespan.Rheumatology (Oxford, England) · 2024Article
- Comorbidity clusters in patients with rheumatoid arthritis identify a patient phenotype with a favourable prognosis.Annals of the rheumatic diseases · 2024Article
- Multiple morbidities are associated with serious infections in patients with rheumatoid arthritis.Seminars in arthritis and rheumatism · 2024Article
- Mortality Trends Among Patients with Rheumatoid Arthritis in Western Australia.Rheumatology and therapy · 2023Article
- Multimorbidity status and annual healthcare expenditures of rheumatoid arthritis patients: a Dutch hospital-centered versus population-based comparison.Rheumatology international · 2023Article
- Using Unsupervised Machine Learning Methods to Cluster Comorbidities in a Population-Based Cohort of Patients With Rheumatoid Arthritis.Arthritis care & research · 2023Article
- Racial Differences in Multimorbidity and Comorbidities in Rheumatoid Arthritis.Arthritis care & research · 2023Article
- The point of no return? Functional disability transitions in patients with and without rheumatoid arthritis: A population-based cohort study.Seminars in arthritis and rheumatism · 2022Article
- Comprehensive assessment of multimorbidity burden in a population-based cohort of patients with rheumatoid arthritis.RMD open · 2022Article
- Predictors of health-related quality of life in musculoskeletal disease patients: a longitudinal analysis.Therapeutic advances in musculoskeletal disease · 2021Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
objectiveMultimorbidity (the coexistence of two or more long-term conditions) is highly prevalent in people who have rheumatoid arthritis (RA). The present work systematically reviewed the literature to determine the effect of multimorbidity on all-cause mortality, functional status, and quality of life in RA.
methodsSix electronic databases were searched: CINAHL, The Cochrane Library, Embase, Medline, PsycINFO, and Scopus. Full-text longitudinal observational studies in English were selected. Quality appraisal of studies was undertaken using the Cochrane-developed QUIPS tool and a narrative synthesis of findings conducted.
resultsThe search strategy identified 5,343 articles, with 19 studies meeting the inclusion criteria. Nine studies had mortality as an outcome, 9 reported functional status and/or quality of life, and 1 study reported both mortality and functional status. The number of participants ranged from 183 to 18,485, with studies conducted between 1985 and 2018. The mean age of participants ranged from 52.0 to 66.6 years, and 60.0-88.0% were female. Nine studies showed a significant association between multimorbidity and higher risk of mortality in people with RA. Ten studies reported significant associations between multimorbidity and reduced functional status in RA. Three studies also showed a further association with reduced quality of life. Only one study investigated the influence of mental health comorbidities on outcomes.
conclusionOur review findings indicate that multimorbidity is a significant predictor for higher mortality and poorer functional status/quality of life in people with RA and should be considered in clinical management plans.
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