Evidence map›Paper›PMID 33650031›Full record

ArticleMolecular diversity2022

Dihydroquinazolin-4(1H)-one derivatives as novel and potential leads for diabetic management.

Oluwatoyin Babatunde, Shehryar Hameed, Uzma Salar, Sridevi Chigurupati, Abdul Wadood, Ashfaq Ur Rehman, Vijayan Venugopal, Khalid Mohammed Khan, Muhammad Taha, Shahnaz Perveen

Abstract read
PubMed Publisher
In one paragraph

Article in Molecular diversity, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.7field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 22 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 7 institutions in 4 countries.

Oluwatoyin BabatundeH. E. J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi, 75270, Pakistan.
Shehryar HameedH. E. J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi, 75270, Pakistan.
Uzma SalarDr. Panjwani Center for Molecular Medicine and Drug Research, International Center for Chemical and Biological Sciences, University of Karachi, Karachi, 75270, Pakistan.
Sridevi ChigurupatiDepartment of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, Qassim University, Buraidah, 52571, Saudi Arabia.
Abdul WadoodDepartment of Biochemistry, Computational Medicinal Chemistry Laboratory, UCSS, Abdul Wali Khan University, Mardan, Pakistan.
Ashfaq Ur RehmanDepartment of Biochemistry, Computational Medicinal Chemistry Laboratory, UCSS, Abdul Wali Khan University, Mardan, Pakistan.
Vijayan VenugopalFaculty of Pharmacy, AIMST University, 08100, Kedah, Malaysia.
Khalid Mohammed KhanH. E. J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi, 75270, Pakistan. khalid.khan@iccs.edu.ORCID http://orcid.org/0000-0001-8337-4021
Muhammad TahaDepartment of Clinical Pharmacy, Institute for Research and Medical Consultations (IRMC), Imam Abdulrahman Bin Faisal University, P.O. Box 1982, Dammam, 31441, Saudi Arabia.
Shahnaz PerveenPCSIR Laboratories Complex, Karachi, Shahrah-e-Dr. Salimuzzaman Siddiqui, Karachi, 75280, Pakistan.
University of Karachi · PKAbdul Wali Khan University Mardan · PKAIMST University · MYImam Abdulrahman Bin Faisal University · SAInternational Center for Chemical and Biological Sciences · PKKarachi Medical and Dental College · PKQassim University · SA

Funding

Pakistan Academy of Sciences 5-9/PAS/440
6 · The paper itself

Abstract

A variety of dihydroquinazolin-4(1H)-one derivatives (1-37) were synthesized via "one-pot" three-component reaction scheme by treating aniline and different aromatic aldehydes with isatoic anhydride in the presence of acetic acid. Chemical structures of compounds were deduced by different spectroscopic techniques including EI-MS, HREI-MS,

Indexed as

alpha-GlucosidasesDiabetes Mellitusalpha-AmylasesGlycoside Hydrolase InhibitorsHumansKineticsMagnetic Resonance SpectroscopyMolecular Docking Simulationalpha-Amylasesalpha-GlucosidasesGlycoside Hydrolase InhibitorsAcarboseDiabetesDual inhibitorsHyperglycemiaIn silicoKinetic studiesQuinazolinoneα-amylaseα-glucosidase

Identifiers

PMID33650031
OpenAlexW3134167581

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.