Evidence map›Paper›PMID 33649986›Full record

ArticleJournal of cardiovascular translational research2021

Proteoglycan Remodeling Is Accelerated in Females with Angina Pectoris and Diffuse Myocardial Fibrosis: the iPOWER Study.

Naja Dam Mygind, Signe Holm Nielsen, Marie Mide Michelsen, Adam Pena, Daria Frestad Bechsgaard, Elena Suhrs, Kira Bang Bove, Federica Genovese, Henning Bay Nielsen, Morten Karsdal and 3 more

Abstract read
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Article in Journal of cardiovascular translational research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 97% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 2 institutions in 1 country.

Naja Dam MygindDepartment of Cardiology, Bispebjerg Hospital, University of Copenhagen, Copenhagen, Denmark. ndmygind@dadlnet.dk.ORCID 0000-0001-5592-5148
Signe Holm NielsenFibrosis Biology and Biomarkers, Nordic Bioscience A/S, Herlev, Denmark.
Marie Mide MichelsenDepartment of Cardiology, Bispebjerg Hospital, University of Copenhagen, Copenhagen, Denmark.
Adam PenaDepartment of Cardiology, Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark.
Daria Frestad BechsgaardDepartment of Cardiology, Hvidovre Hospital, University of Copenhagen, Copenhagen, Denmark.
Elena SuhrsDepartment of Cardiology, Bispebjerg Hospital, University of Copenhagen, Copenhagen, Denmark.
Kira Bang BoveDepartment of Cardiology, Bispebjerg Hospital, University of Copenhagen, Copenhagen, Denmark.
Federica GenoveseFibrosis Biology and Biomarkers, Nordic Bioscience A/S, Herlev, Denmark.
Henning Bay NielsenSanos Clinics A/S, Herlev, Denmark.
Morten KarsdalFibrosis Biology and Biomarkers, Nordic Bioscience A/S, Herlev, Denmark.
Niels VejlstrupDepartment of Cardiology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
Eva PrescottDepartment of Cardiology, Bispebjerg Hospital, University of Copenhagen, Copenhagen, Denmark.
Jens KastrupDepartment of Cardiology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
University of Copenhagen · DKNordic Bioscience (Denmark) · DK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Angina and no obstructive coronary artery disease (CAD) have an unfavorable prognosis, possibly due to diffuse myocardial fibrosis (DMF). In DMF the proteoglycans biglycan and versican are actively remodeled by matrix metalloproteinase. We investigated biglycan and versican in females with angina and possible DMF assessed by cardiac magnetic resonance (CMR). Seventy-one females with angina and no obstructive CAD were included. Asymptomatic females served as controls. Versican and biglycan were measured and CMR was performed measuring extracellular volume. Biglycan and versican levels were higher in symptomatic females compared with controls; 31.4 ng/mL vs. 16.4 ng/mL (p < 0.001) and 2.1 ng/mL vs. 1.8 ng/mL (p < 0.001) and moderately correlated to extracellular volume (r

Indexed as

AgedAngina PectorisBiglycanBiomarkersCase-Control StudiesCoronary Artery DiseaseFemaleFibrosisHumansMagnetic Resonance ImagingMiddle AgedMyocardiumVersicansBGN protein, humanBiglycanBiomarkersVCAN protein, humanVersicansAngina pectorisCardiac magnetic resonanceCoronary microvascular diseaseDiffuse myocardial fibrosisExtracellular matrixProteoglycanT1 mapping

Identifiers

PMID33649986
OpenAlexW3133590905

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.