ArticleArchives of osteoporosis2021
FRAX-based fracture probabilities in South Africa.
Article in Archives of osteoporosis, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Bone Mineral Density in Black South African Women Newly Diagnosed With Breast Cancer Living With and Without HIV.JCO global oncology · 2025Article
- A surrogate FRAX model for Nepal.Archives of osteoporosis · 2024Article
- Prevalence of HIV-associated osteoporosis and fracture risk in midlife women: a cross-sectional study in Zimbabwe.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2024Article
- Bone Loss and Fractures in Post-Menopausal Women Living with HIV: A Narrative Review.Pathogens (Basel, Switzerland) · 2024Review
- Enhanced osteogenic differentiation in 3D hydrogel scaffold via macrophage mitochondrial transfer.Journal of nanobiotechnology · 2024Article
- Race-specific FRAX models are evidence-based and support equitable care: a response to the ASBMR Task Force report on Clinical Algorithms for Fracture Risk.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2024Article
- A comprehensive review on the impact of calcium and vitamin D insufficiency and allied metabolic disorders in females.Food science & nutrition · 2023Review
- Disparities in the Prevalence of Osteoporosis and Osteopenia in Men and Women Living in Sub-Saharan Africa, the UK, and the USA.Current osteoporosis reports · 2023Review
- The Impact of Human Immunodeficiency Virus and Menopause on Bone Mineral Density: A Longitudinal Study of Urban-Dwelling South African Women.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2023Article
- Incidence and number of fragility fractures of the hip in South Africa: estimated projections from 2020 to 2050.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2022Article
- Calcium deficiency worldwide: prevalence of inadequate intakes and associated health outcomes.Annals of the New York Academy of Sciences · 2022Article
- Osteoporosis, Rather Than Sarcopenia, Is the Predominant Musculoskeletal Disease in a Rural South African Community Where Human Immunodeficiency Virus Prevalence Is High: A Cross-Sectional Study.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2022Article
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Authors and funding
17 authors.
Funding
Abstract
The hip fracture rates in South Africa were used to create ethnic-specific FRAX® models to facilitate fracture risk assessment.
introductionThe aim of this study was to develop FRAX models to compute the 10-year probability of hip fracture and major osteoporotic fracture and assess their potential clinical application.
methodsAge- and sex-specific incidence of hip fracture and national mortality rates were incorporated into a FRAX model for the White, Black African, Coloured and Indian population of South Africa. Age-specific 10-year probabilities of a major osteoporotic fracture were calculated in women to determine fracture probabilities at a femoral neck T score of -2.5 SD, or those equivalent to a woman with a prior fragility fracture. Fracture probabilities were compared with those from selected countries.
resultsProbabilities were consistently higher in Indian than in Coloured men and women, in turn, higher than in Black South Africans. For White South Africans, probabilities were lower than in Indians at young ages up to the age of about 80 years. When a BMD T score of -2.5 SD was used as an intervention threshold, FRAX probabilities in women age 50 years were approximately 2-fold higher than in women of the same age but with an average BMD and no risk factors. The increment in risk associated with the BMD threshold decreased progressively with age such that, at the age of 80 years or more, a T score of -2.5 SD was no longer a risk factor. Probabilities equivalent to women with a previous fracture rose with age and identified women at increased risk at all ages.
conclusionsThese FRAX models should enhance accuracy of determining fracture probability amongst the South African population and help guide decisions about treatment.
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