Evidence map›Paper›PMID 33649851›Full record

ArticleOncology reports2021

Semaphorin 4D is a potential biomarker in pediatric leukemia and promotes leukemogenesis by activating PI3K/AKT and ERK signaling pathways.

Hongchao Jiang, Jiaolian Tang, Lijuan Qiu, Zhen Zhang, Shulan Shi, Li Xue, Liyue Kui, Tilong Huang, Weiwei Nan, Bailing Zhou and 3 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Oncology reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
2.0field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 27 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 1 country.

Hongchao Jiang *Institute of Pediatrics, The Kunming Children's Hospital, Kunming, Yunnan 650228, P.R. China.
Jiaolian Tang *Institute of Pediatrics, Children's Hospital Affiliated to Kunming Medical University, Kunming, Yunnan 650228, P.R. China.
Lijuan Qiu *Institute of Pediatrics, The Kunming Children's Hospital, Kunming, Yunnan 650228, P.R. China.
Zhen ZhangInstitute of Pediatrics, The Kunming Children's Hospital, Kunming, Yunnan 650228, P.R. China.
Shulan ShiInstitute of Pediatrics, The Kunming Children's Hospital, Kunming, Yunnan 650228, P.R. China.
Li XueInstitute of Medicine, Dali University, Dali, Yunnan 671000, P.R. China.
Liyue KuiInstitute of Pediatrics, The Kunming Children's Hospital, Kunming, Yunnan 650228, P.R. China.
Tilong HuangInstitute of Pediatrics, The Kunming Children's Hospital, Kunming, Yunnan 650228, P.R. China.
Weiwei NanInstitute of Medicine, Dali University, Dali, Yunnan 671000, P.R. China.
Bailing ZhouInstitute of Pediatrics, The Kunming Children's Hospital, Kunming, Yunnan 650228, P.R. China.
Canchun ZhaoInstitute of Pediatrics, The Kunming Children's Hospital, Kunming, Yunnan 650228, P.R. China.
Ming YuYunnan Key Laboratory of Stem Cell and Regenerative Medicine, Biomedical Engineering Research Center, Kunming Medical University, Kunming, Yunnan 650500, P.R. China.
Qiangming SunInstitute of Medical Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Kunming, Yunnan 650118, P.R. China.
Kunming Children's Hospital · CNDali University · CNKunming Medical University · CNChinese Academy of Medical Sciences & Peking Union Medical College · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Semaphorin 4D (Sema4D) is highly expressed in a variety of tumors and is associated with high invasion, poor prognosis and poor therapeutic response. However, the expression and role of Sema4D in leukemia remains unclear. The present study investigated the expression of Sema4D in pediatric leukemia and its effects in leukemia cells. The results demonstrated that Sema4D protein was highly expressed in peripheral blood mononuclear cells of patients with pediatric leukemia, and high levels of soluble Sema4D were also observed in the plasma of these patients. Sema4D knockdown induced cell cycle arrest in G

Indexed as

MAP Kinase Signaling SystemAdolescentAntigens, CDBiomarkers, TumorCase-Control StudiesCell Line, TumorCell ProliferationChildChild, PreschoolFemaleHumansInfantJurkat CellsLeukemia, Myeloid, AcuteLeukocytes, MononuclearMaleAntigens, CDBiomarkers, TumorCD100 antigenPhosphatidylinositol 3-KinasesProto-Oncogene Proteins c-aktSemaphorinsbiomarkerERKleukemiaPI3KSEMA4D

Identifiers

PMID33649851
PMCPMC7877000
OpenAlexW3121843541

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.