Evidence map›Paper›PMID 33649821›Full record

ArticleInternational journal of oncology2021

Circ_0000511 accelerates the proliferation, migration and invasion, and restrains the apoptosis of breast cancer cells through the miR‑326/TAZ axis.

Di Wu, Hongyao Jia, Zhiru Zhang, Sijie Li

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of oncology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
1.6field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 26 citations in OpenAlex.

  1. Review
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  10. Roles and Mechanisms of Long Non-Coding RNAs in Breast Cancer.International journal of molecular sciences · 2022
    Review
  11. Article
  12. A novel causal model for nasopharyngeal carcinoma.Cancer causes & control : CCC · 2022
    Article
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  14. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Di Wu *Department of Breast Surgery, The First Hospital of Jilin University, Changchun, Jilin 130021, P.R. China.
Hongyao Jia *Department of Breast Surgery, The First Hospital of Jilin University, Changchun, Jilin 130021, P.R. China.
Zhiru ZhangDepartment of Breast Surgery, The First Hospital of Jilin University, Changchun, Jilin 130021, P.R. China.
Sijie LiDepartment of Breast Surgery, The First Hospital of Jilin University, Changchun, Jilin 130021, P.R. China.
First Hospital of Jilin University · CNJilin University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Circular RNA 0000511 (circ_0000511) has been observed to be dysregulated in breast cancer (BC). However, the functions of circ_0000511 in breast cancer remain unknown. The expression levels of circ_0000511, ribonuclease P RNA component H1, microRNA‑326 (miR‑326) and transcriptional co‑activator with PDZ‑binding motif (TAZ) were examined by reverse transcription‑quantitative PCR. Colony formation and MTT assays were conducted to analyze the cellular proliferative ability. The apoptotic rate was assessed by flow cytometry. Western blot analysis was used to evaluate the expression levels of B cell leukemia/lymphoma 2 (Bcl‑2), Bcl‑2 associated X apoptosis regulator, cleaved caspase‑3 and TAZ. Transwell assays were performed to evaluate the migration and invasion of BC cells. The target interaction between miR‑326 and circ_0000511 or TAZ was confirmed by dual‑luciferase reporter assay. Xenograft assay was used to identify the function of circ_0000511

Indexed as

AdultAgedAged, 80 and overAnimalsApoptosisBreast NeoplasmsCell Line, TumorCell MovementCell ProliferationFemaleHeterograftsHumansIntracellular Signaling Peptides and ProteinsMCF-7 CellsMiceMice, Inbred BALB CIntracellular Signaling Peptides and ProteinsMicroRNAsMIRN326 microRNA, humanRNA, CircularTranscriptional Coactivator with PDZ-Binding Motif ProteinsWWTR1 protein, humanbreast cancercircular RNA 0000511microRNA‑326transcriptional co‑activator with PDZ‑binding motif

Identifiers

PMID33649821
PMCPMC7891826
OpenAlexW3128995759

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.