Evidence map›Paper›PMID 33649809›Full record

ArticleMolecular medicine reports2021

Hydrogen sulfide ameliorates doxorubicin‑induced myocardial fibrosis in rats via the PI3K/AKT/mTOR pathway.

Liangui Nie, Maojun Liu, Jian Chen, Qian Wu, Yaling Li, Jiali Yi, Xia Zheng, Jingjing Zhang, Chun Chu, Jun Yang

Open access · hybridAbstract read
In one paragraph

Article in Molecular medicine reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
4.6field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 39 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. The potential role of hydrogen sulfide-autophagy axis in diseases.Journal of physiology and biochemistry · 2025
    Review
  6. Article
  7. Emerging Research and Future Directions on Doxorubicin: A Snapshot.Asian Pacific journal of cancer prevention : APJCP · 2025
    Review
  8. Review
  9. Review
  10. Article
  11. Review
  12. Article
  13. Review
  14. Article
  15. Article
  16. Article
  17. The Role of Hydrogen Sulfide Regulation of Autophagy in Liver Disorders.International journal of molecular sciences · 2022
    Review
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Liangui Nie *Department of Cardiology, The First Affiliated Hospital of University of South China, Hengyang, Hunan 421001, P.R. China.
Maojun Liu *Department of Cardiology, The First Affiliated Hospital of University of South China, Hengyang, Hunan 421001, P.R. China.
Jian ChenDepartment of Cardiology, The First Affiliated Hospital of University of South China, Hengyang, Hunan 421001, P.R. China.
Qian WuDepartment of Cardiology, The First Affiliated Hospital of University of South China, Hengyang, Hunan 421001, P.R. China.
Yaling LiDepartment of Cardiology, The First Affiliated Hospital of University of South China, Hengyang, Hunan 421001, P.R. China.
Jiali YiDepartment of Cardiology, The First Affiliated Hospital of University of South China, Hengyang, Hunan 421001, P.R. China.
Xia ZhengDepartment of Cardiology, The First Affiliated Hospital of University of South China, Hengyang, Hunan 421001, P.R. China.
Jingjing ZhangDepartment of Cardiology, The First Affiliated Hospital of University of South China, Hengyang, Hunan 421001, P.R. China.
Chun ChuDepartment of Pharmacy, The Second Affiliated Hospital of University of South China, Hengyang, Hunan 421001, P.R. China.
Jun YangDepartment of Cardiology, The First Affiliated Hospital of University of South China, Hengyang, Hunan 421001, P.R. China.
University of South China · CNFirst Affiliated Hospital of University of South China · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The present study aimed to determine the role and regulatory mechanism of hydrogen sulfide (H

Indexed as

AnimalsAutophagyAutophagy-Related ProteinsCollagenDoxorubicinEndoplasmic Reticulum StressFibrosisGene ExpressionHydrogen SulfideMaleMicroscopy, Electron, TransmissionMyocardiumPhosphatidylinositol 3-KinasesProto-Oncogene Proteins c-aktRatsRats, Sprague-DawleyAutophagy-Related ProteinsCollagenDoxorubicinHydrogen SulfideMTOR protein, humanPhosphatidylinositol 3-KinasesProto-Oncogene Proteins c-aktTOR Serine-Threonine KinasesTransforming Growth Factor beta1autophagydoxorubicinendoplasmic reticulum stresshydrogen sulfidemyocardial fibrosisPI3K/AKT/mTOR signaling pathway

Identifiers

PMID33649809
PMCPMC7930940
OpenAlexW3132547656

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.