Evidence map›Paper›PMID 33649709›Full record

ArticleThe annals of applied statistics2020

A causal exposure response function with local adjustment for confounding: Estimating health effects of exposure to low levels of ambient fine particulate matter.

Georgia Papadogeorgou, Francesca Dominici

Open access · bronzeAbstract read
In one paragraph

Article in The annals of applied statistics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact, top 100% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 0 citations in OpenAlex.

  1. Towards a burden of disease research agenda.Population health metrics · 2026
    Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Review
  7. Article
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Georgia PapadogeorgouDepartment of Statistical Science, Duke University, Durham NC 27710.
Francesca DominiciDepartment of Biostatistics, Harvard T.H. Chan School of Public Health, Boston MA 02115.
Harvard University · US

Funding

Cardiovascular Health and Air Pollution: A National StudyR01ES024332 · NIEHS · HARVARD SCHOOL OF PUBLIC HEALTH · PI ZANOBETTI, ANTONELLA · 2015 to 2018
$2.5M
Bayesian Methods for Comparative Effectiveness Research with Observational DataR01GM111339 · NIGMS · HARVARD MEDICAL SCHOOL · PI NORMAND, SHARON-LISE TERESA · 2015 to 2018
$2.5M
NIEHS NIH HHS R01 ES024332NIGMS NIH HHS R01 GM111339
6 · The paper itself

Abstract

In the last two decades, ambient levels of air pollution have declined substantially. At the same time, the Clean Air Act mandates that the National Ambient Air Quality Standards (NAAQS) must be routinely assessed to protect populations based on the latest science. Therefore, researchers should continue to address the following question: is exposure to levels of air pollution below the NAAQS harmful to human health? Furthermore, the contentious nature surrounding environmental regulations urges us to cast this question within a causal inference framework. Several parametric and semi-parametric regression approaches have been used to estimate the exposure-response (ER) curve between long-term exposure to ambient air pollution concentrations and health outcomes. However, most of the existing approaches are not formulated within a formal framework for causal inference, adjust for the same set of potential confounders across all levels of exposure, and do not account for model uncertainty regarding covariate selection and the shape of the ER. In this paper, we introduce a Bayesian framework for the estimation of a causal ER curve called LERCA (Local Exposure Response Confounding Adjustment), which a) allows for different confounders

Indexed as

air pollutioncardiovascular hospitalizationscausal inferenceexposure response functionlocal confoundinglow exposure levelsparticulate matter

Identifiers

PMID33649709
PMCPMC7914396
OpenAlexW2999143241

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.