ArticleOptics letters2021
Spatial-frequency-based image reconstruction to improve image contrast in multi-offset adaptive optics ophthalmoscopy.
Article in Optics letters, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 18 citations in OpenAlex.
- Revealing neurovascular coupling at a high spatial and temporal resolution in the living human retina.Science advances · 2025Article
- Deep compressed multichannel adaptive optics scanning light ophthalmoscope.Science advances · 2025Article
- Quantification of optical lensing by cellular structures in the living human eye.Biomedical optics express · 2025Article
- Are the Hypo-Reflective Clumps Associated With Age-Related Macular Degeneration in Adaptive Optics Ophthalmoscopy Autofluorescent?Investigative ophthalmology & visual science · 2024Article
- High-speed, phase contrast retinal and blood flow imaging using an adaptive optics partially confocal multi-line ophthalmoscope.Biomedical optics express · 2024Article
- Minimum intensity projection of embossed quadrant-detection images for improved photoreceptor mosaic visualisation.Frontiers in ophthalmology · 2024Article
- Insights into Sickle Cell Disease through the Retinal Microvasculature: Adaptive Optics Scanning Light Ophthalmoscopy Correlates of Clinical OCT Angiography.Ophthalmology science · 2022Article
- Imaging of vitreous cortex hyalocyte dynamics using non-confocal quadrant-detection adaptive optics scanning light ophthalmoscopy in human subjects.Biomedical optics express · 2022Article
- Design of a radial multi-offset detection pattern forBiomedical optics express · 2022Article
- Label-Free Imaging of Inflammation at the Level of Single Cells in the Living Human Eye.Ophthalmology scienceArticle
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
Abstract
Off-axis detection methods in adaptive optics (AO) ophthalmoscopy can enhance image contrast of translucent retinal structures such as cone inner segments and retinal ganglion cells. Here, we propose a 2D optical model showing that the phase contrast produced by these methods depends on the offset orientation. While one axis provides an asymmetric light distribution, hence high phase contrast, the perpendicular axis provides a symmetric one, thus substantially lower contrast. We support this model with in vivo human data acquired with a multi-offset AO scanning light ophthalmoscope. Then, using this finding, we provide a post-processing method, named spatial-frequency-based image reconstruction, to optimally combine images from different off-axis detector orientations, significantly increasing the structural cellular contrast of in vivo human retinal neurons such as cone inner segment, putative rods, and retinal ganglion cells.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.