ArticleThe ISME journal2021
Host genetics exerts lifelong effects upon hindgut microbiota and its association with bovine growth and immunity.
Article in The ISME journal, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 59 papers.
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Who cites it
59 citing papers in PubMed, 133 citations in OpenAlex.
- Beyond the Rumen: Current Evidence and Knowledge Gaps in Microbial Diversity and Function Across the Bovine Gastrointestinal Tract.Current microbiology · 2026Review
- Sheep-derived probiotics alleviate weaning-induced oxidative stress in lambs via the gut-liver axis.NPJ biofilms and microbiomes · 2026Article
- Bidirectional regulation of gut microbiota and young ruminant host: implications for intestinal development and mucosal immunity.Journal of animal science and biotechnology · 2026Review
- Integrated Multi-Omics Analysis Reveals the Role of the Gut Microbiota-Metabolite-Endocrine Axis in Post-Weaning Estrus Recovery in Tibetan Pigs.Animals : an open access journal from MDPI · 2026Article
- Harnessing the early-life gut microbiome for sustainable ruminant production.Animal microbiome · 2026Review
- Understanding the influence of sward type and dairy cow breed on enteric methane emissions through investigation of the rumen microbiome.Frontiers in microbiology · 2026Article
- Exploring genome, transcriptome, and microbiome interactions related to feed efficiency and methane emissions in Bos indicus through multi-omics network analysis.Mammalian genome : official journal of the International Mammalian Genome Society · 2025Article
- Prediction accuracy for feed intake and body weight gain using host genomic and rumen metagenomic data in beef cattle.Genetics, selection, evolution : GSE · 2025Article
- Characterizing Gut Microbiota Composition and Its Correlation with Growth Variation in Sea Cucumber Apostichopus japonicus.Marine biotechnology (New York, N.Y.) · 2025Article
- Effects and Microbiota Changes Following Oral Lyophilized Fecal Microbiota Transplantation Capsules in Canine with Chronic Enteropathy After Parvovirus Infection: Case Report.Veterinary sciences · 2025Article
- Host genetic regulation of specific functional groups in the rumen microbiome of dairy cows: Implications for lactation trait.Journal of advanced research · 2025Article
- Establishment and development of the gut microbiota in dairy goats during the early life.BMC veterinary research · 2025Article
- Bacterial indicators of environmental stress in the gut microbiome of free-ranging European roe deer inhabiting agricultural landscapes.Scientific reports · 2025Article
- The bacterial faecal microbiota shifts during the transition period in dairy cows.Animal microbiome · 2025Article
- 16S rRNA and Metagenomic Datasets of Gastrointestinal Microbiota in Fetal and 7-Day-Old Goat Kids.Scientific data · 2025Article
- Sequence-based GWAS reveals genes and variants associated with predicted methane emissions in French dairy cows.Genetics, selection, evolution : GSE · 2025Article
- The Joint Contribution of Host Genetics and Probiotics to Pig Growth Performance.Microorganisms · 2025Article
- Dynamics of Intestinal Mucosa Microbiota in Juvenile Sika Deer During Early Growth.International journal of molecular sciences · 2025Article
- Ecological and Functional Changes in the Hindgut Microbiome of Holstein Cows at High Altitudes.Animals : an open access journal from MDPI · 2025Article
- Characterization of blood microbial population in beef calves with clinical signs of sepsis using 16S rRNA gene sequencing.PloS one · 2025Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The gut microbiota is a complex ecological community that plays multiple critical roles within a host. Known intrinsic and extrinsic factors affect gut microbiota structure, but the influence of host genetics is understudied. To investigate the role of host genetics upon the gut microbiota structure, we performed a longitudinal study in which we evaluated the hindgut microbiota and its association with animal growth and immunity across life. We evaluated three different growth stages in an Angus-Brahman multibreed population with a graduated spectrum of genetic variation, raised under variable environmental conditions and diets. We found the gut microbiota structure was changed significantly during growth when preweaning, and fattening calves experienced large variations in diet and environmental changes. However, regardless of the growth stage, we found gut microbiota is significantly influenced by breed composition throughout life. Host genetics explained the relative abundances of 52.2%, 40.0%, and 37.3% of core bacterial taxa at the genus level in preweaning, postweaning, and fattening calves, respectively. Sutterella, Oscillospira, and Roseburia were consistently associated with breed composition at these three growth stages. Especially, butyrate-producing bacteria, Roseburia and Oscillospira, were associated with nine single-nucleotide polymorphisms (SNPs) located in genes involved in the regulation of host immunity and metabolism in the hindgut. Furthermore, minor allele frequency analysis found breed-associated SNPs in the short-chain fatty acids (SCFAs) receptor genes that promote anti-inflammation and enhance intestinal epithelial barrier functions. Our findings provide evidence of dynamic and lifelong host genetic effects upon gut microbiota, regardless of growth stages. We propose that diet, environmental changes, and genetic components may explain observed variation in critical hindgut microbiota throughout life.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.