Evidence map›Paper›PMID 33649522›Full record

SynthesisThe pharmacogenomics journal2021

Genetic meta-analysis of cancer diagnosis following statin use identifies new associations and implicates human leukocyte antigen (HLA) in women.

Maxine Sun, Audrey Lemaçon, Marc-André Legault, Géraldine Asselin, Sylvie Provost, Hugues Aschard, Amina Barhdadi, Yassamin Feroz Zada, Diane Valois, Ian Mongrain and 2 more

Abstract readMeta-Analysis
PubMed Publisher
In one paragraph

Synthesis in The pharmacogenomics journal, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.4field-weighted citation impact, top 48% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Immunogenetic clustering of 30 cancers.Scientific reports · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 2 countries.

Maxine SunUniversité de Montréal Beaulieu-Saucier Pharmacogenomics Center, Montreal, QC, Canada.ORCID http://orcid.org/0000-0002-0539-3646
Audrey LemaçonUniversité de Montréal Beaulieu-Saucier Pharmacogenomics Center, Montreal, QC, Canada.ORCID http://orcid.org/0000-0002-1817-7029
Marc-André LegaultUniversité de Montréal Beaulieu-Saucier Pharmacogenomics Center, Montreal, QC, Canada.ORCID http://orcid.org/0000-0001-6927-1210
Géraldine AsselinUniversité de Montréal Beaulieu-Saucier Pharmacogenomics Center, Montreal, QC, Canada.ORCID http://orcid.org/0000-0002-3702-2962
Sylvie ProvostUniversité de Montréal Beaulieu-Saucier Pharmacogenomics Center, Montreal, QC, Canada.
Hugues AschardCentre de Bioinformatique, Biostatistique et Biologie Intégrative (C3BI), Institut Pasteur, Paris, France.ORCID http://orcid.org/0000-0002-7554-6783
Amina BarhdadiUniversité de Montréal Beaulieu-Saucier Pharmacogenomics Center, Montreal, QC, Canada.
Yassamin Feroz ZadaMontreal Heart Institute, Montreal, QC, Canada.
Diane ValoisUniversité de Montréal Beaulieu-Saucier Pharmacogenomics Center, Montreal, QC, Canada.
Ian MongrainUniversité de Montréal Beaulieu-Saucier Pharmacogenomics Center, Montreal, QC, Canada.
Jean-Claude Tardif *Montreal Heart Institute, Montreal, QC, Canada.ORCID http://orcid.org/0000-0002-8200-8983
Marie-Pierre Dubé *Université de Montréal Beaulieu-Saucier Pharmacogenomics Center, Montreal, QC, Canada. marie-pierre.dube@umontreal.ca.ORCID http://orcid.org/0000-0001-8442-4393
Montreal Heart Institute · CAInstitut Pasteur · FR

Funding

Department of HealthMedical Research Council MC_PC_17228Medical Research Council MC_QA137853
6 · The paper itself

Abstract

We sought to perform a genomic evaluation of the risk of incident cancer in statin users, free of cancer at study entry. Patients who previously participated in two phase IV trials (TNT and IDEAL) with genetic data were used (n

Indexed as

AdultAgedCohort StudiesCoronary Artery DiseaseFemaleGenetic VariationGenomicsHLA AntigensHumansHydroxymethylglutaryl-CoA Reductase InhibitorsMaleMiddle AgedNeoplasmsProportional Hazards ModelsRandomized Controlled Trials as TopicRisk FactorsHLA AntigensHydroxymethylglutaryl-CoA Reductase Inhibitors

Identifiers

PMID33649522
OpenAlexW3133494459

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.