Evidence map›Paper›PMID 33649515›Full record

ArticleThe pharmacogenomics journal2021

Functional CYP3A variants affecting tacrolimus trough blood concentrations in Chinese renal transplant recipients.

Dina Chen, Huijie Lu, Weiguo Sui, Liqing Li, Jian Xu, Tengfei Yang, Siyao Yang, Ping Zheng, Yan Chen, Jiejing Chen and 10 more

Abstract read
PubMed Publisher
In one paragraph

Article in The pharmacogenomics journal, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.9field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors at 5 institutions in 2 countries.

Dina Chen *Department of Medical Genetics, School of Basic Medical Sciences, Southern Medical University, Guangzhou, Guangdong, China.
Huijie Lu *Department of Medical Genetics, School of Basic Medical Sciences, Southern Medical University, Guangzhou, Guangdong, China.
Weiguo Sui *Guangxi Key laboratory of Metabolic Diseases Research, Nephrology Department of Guilin NO. 924 Hospital, Guilin, Guangxi, China.
Liqing LiDepartment of Medical Genetics, School of Basic Medical Sciences, Southern Medical University, Guangzhou, Guangdong, China.
Jian XuDepartment of Organ Transplantation, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China.
Tengfei YangDepartment of Medical Genetics, School of Basic Medical Sciences, Southern Medical University, Guangzhou, Guangdong, China.
Siyao YangDepartment of Medical Genetics, School of Basic Medical Sciences, Southern Medical University, Guangzhou, Guangdong, China.
Ping ZhengDepartment of Pharmacy, Nanfang hospital, Southern Medical University, Guangzhou, Guangdong, China.
Yan ChenDepartment of Pharmacy, Nanfang hospital, Southern Medical University, Guangzhou, Guangdong, China.
Jiejing ChenGuangxi Key laboratory of Metabolic Diseases Research, Nephrology Department of Guilin NO. 924 Hospital, Guilin, Guangxi, China.
Wen XueGuangxi Key laboratory of Metabolic Diseases Research, Nephrology Department of Guilin NO. 924 Hospital, Guilin, Guangxi, China.
Qingping LiDepartment of Hepatobiliary Surgery, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China.
Que ZhengDepartment of Medical Genetics, School of Basic Medical Sciences, Southern Medical University, Guangzhou, Guangdong, China.
Demei YeDepartment of Medical Genetics, School of Basic Medical Sciences, Southern Medical University, Guangzhou, Guangdong, China.
Wolfgang SadeeCenter for Pharmacogenomics, Department of Cancer Biology and Genetics, College of Medicine, The Ohio State University, Columbus, OH, USA.
Danxin WangCenter for Pharmacogenomics, Department of Pharmacotherapy and Translational Research, College of Pharmacy, University of Florida, Gainesville, FL, USA.ORCID http://orcid.org/0000-0002-7134-3065
Wanying QianDepartment of Medical Genetics, School of Basic Medical Sciences, Southern Medical University, Guangzhou, Guangdong, China.
Liusheng LaiGuangxi Key laboratory of Metabolic Diseases Research, Nephrology Department of Guilin NO. 924 Hospital, Guilin, Guangxi, China.
Chuanjiang LiDepartment of Hepatobiliary Surgery, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China. licj@smu.edu.cn.ORCID http://orcid.org/0000-0002-3583-2881
Liang LiDepartment of Medical Genetics, School of Basic Medical Sciences, Southern Medical University, Guangzhou, Guangdong, China. liliang@smu.edu.cn.ORCID http://orcid.org/0000-0002-0687-074X
Southern Medical University · CNGuilin Medical University · CNNanfang Hospital · CNThe Ohio State University · USUniversity of Florida · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The aim of this study was to identify novel genetic variants affecting tacrolimus trough blood concentrations. We analyzed the association between 58 single nucleotide polymorphisms (SNPs) across the CYP3A gene cluster and the log-transformed tacrolimus concentration/dose ratio (log (C

Indexed as

Kidney TransplantationAdultAgingAsian PeopleCohort StudiesCreatinineCytochrome P-450 CYP3AFemaleGenetic VariationHematocritHumansImmunosuppressive AgentsMaleMiddle AgedPolymorphism, Single NucleotideTacrolimusCreatinineCYP3A protein, humanCytochrome P-450 CYP3AImmunosuppressive AgentsTacrolimus

Identifiers

PMID33649515
OpenAlexW3134206589

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.