Evidence map›Paper›PMID 33649513›Full record

ArticleScientific reports2021

Differential effect of anesthetics on mucociliary clearance in vivo in mice.

Kyle S Feldman, Eunwon Kim, Michael J Czachowski, Yijen Wu, Cecilia W Lo, Maliha Zahid

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
2.1field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 16 citations in OpenAlex.

  1. Article
  2. Observational
  3. Review
  4. Article
  5. Review
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  7. Review
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Kyle S FeldmanDepartment of Developmental Biology, Rangos Research Center, University of Pittsburgh School of Medicine, 530 45th St., Pittsburgh, PA, 15201, USA.
Eunwon KimDepartment of Developmental Biology, Rangos Research Center, University of Pittsburgh School of Medicine, 530 45th St., Pittsburgh, PA, 15201, USA.
Michael J CzachowskiDiagnostic Imaging, Tomayko Group, Pittsburgh, PA, USA.
Yijen WuDepartment of Developmental Biology, Rangos Research Center, University of Pittsburgh School of Medicine, 530 45th St., Pittsburgh, PA, 15201, USA.
Cecilia W LoDepartment of Developmental Biology, Rangos Research Center, University of Pittsburgh School of Medicine, 530 45th St., Pittsburgh, PA, 15201, USA.
Maliha ZahidDepartment of Developmental Biology, Rangos Research Center, University of Pittsburgh School of Medicine, 530 45th St., Pittsburgh, PA, 15201, USA. maz7@pitt.edu.
University of Pittsburgh · US

Funding

Targeting Underlying Pathophysiological Mechanisms to Develop Novel Therapies for Chronic Obstructive Lung DiseaseR01HL153407 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI ZAHID, MALIHA · 2020 to 2024
$3.0M
NHLBI NIH HHS R01 HL153407
6 · The paper itself

Abstract

Respiratory mucociliary clearance (MCC) is a key defense mechanism that functions to entrap and transport inhaled pollutants, particulates, and pathogens away from the lungs. Previous work has identified a number of anesthetics to have cilia depressive effects in vitro. Wild-type C57BL/6 J mice received intra-tracheal installation of

Indexed as

Anesthetics, InhalationAnimalsDrug CombinationsMiceMice, Inbred C57BLMucociliary ClearanceAnesthetics, InhalationDrug Combinations

Identifiers

PMID33649513
PMCPMC7921682
OpenAlexW3134198827

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.