ArticleCommunications biology2021
Progression of the late-stage divisome is unaffected by the depletion of the cytoplasmic FtsZ pool.
Article in Communications biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Constitutive, endogenous, fluorescent membrane reporters for dynamic cell cycle analysis inApplied and environmental microbiology · 2026Article
- A novel peptidoglycan deacetylase modulates daughter cell separation in E. coli.PLoS genetics · 2025Article
- Sophisticated natural products as antibiotics.Nature · 2024Review
- Insights into the assembly and regulation of the bacterial divisome.Nature reviews. Microbiology · 2024Review
- Microscopy-Based Multiwell Assay to Characterize Disturbed Bacterial Morphogenesis Upon Antibiotic Action.Methods in molecular biology (Clifton, N.J.) · 2023Article
- Antibiotics: Precious Goods in Changing Times.Methods in molecular biology (Clifton, N.J.) · 2023Article
- Quantitative Analysis of Microscopy Data to Evaluate Bacterial Responses to Antibiotic Treatment.Methods in molecular biology (Clifton, N.J.) · 2023Article
- A tightly controlled gene induction system that contributes to the study of lethal gene function inJournal of oral microbiology · 2023Article
- Antibiotic Acyldepsipeptides Stimulate themBio · 2022Article
- MraZ Transcriptionally Controls the Critical Level of FtsL Required for Focusing Z-Rings and Kickstarting Septation in Bacillus subtilis.Journal of bacteriology · 2022Article
- Article
- Progression of the late-stage divisome is unaffected by the depletion of the cytoplasmic FtsZ pool.Communications biology · 2021Article
- Reprogramming of the Caseinolytic Protease by ADEP Antibiotics: Molecular Mechanism, Cellular Consequences, Therapeutic Potential.Frontiers in molecular biosciences · 2021Review
- Elongation at Midcell in Preparation of Cell Division Requires FtsZ, but Not MreB nor PBP2 inFrontiers in microbiology · 2021Article
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Authors and funding
4 authors.
Funding
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Abstract
Cell division is a central and essential process in most bacteria, and also due to its complexity and highly coordinated nature, it has emerged as a promising new antibiotic target pathway in recent years. We have previously shown that ADEP antibiotics preferably induce the degradation of the major cell division protein FtsZ, thereby primarily leading to a depletion of the cytoplasmic FtsZ pool that is needed for treadmilling FtsZ rings. To further investigate the physiological consequences of ADEP treatment, we here studied the effect of ADEP on the different stages of the FtsZ ring in rod-shaped bacteria. Our data reveal the disintegration of early FtsZ rings during ADEP treatment in Bacillus subtilis, indicating an essential role of the cytoplasmic FtsZ pool and thus FtsZ ring dynamics during initiation and maturation of the divisome. However, progressed FtsZ rings finalized cytokinesis once the septal peptidoglycan synthase PBP2b, a late-stage cell division protein, colocalized at the division site, thus implying that the concentration of the cytoplasmic FtsZ pool and FtsZ ring dynamics are less critical during the late stages of divisome assembly and progression.
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