ReviewMolecular psychiatry2022
A neural model of vulnerability and resilience to stress-related disorders linked to differential susceptibility.
Review in Molecular psychiatry, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
33 citing papers in PubMed, 64 citations in OpenAlex.
- Neurodevelopmental associations linking subtypes of bullying victimization to internalizing and externalizing problems in childhood and adolescence.Developmental cognitive neuroscience · 2026Article
- Changes in Emotional Regulation, Well-Being, and Pain Perception Following Music Therapy in People with Sensory Processing Sensitivity: A Non-Controlled Exploratory Study.Healthcare (Basel, Switzerland) · 2026Article
- Impact of screen time on white matter integrity and neurodevelopment in children with autism spectrum disorder: a diffusional kurtosis imaging mediation analysis.European child & adolescent psychiatry · 2026Article
- Neuroscience-Informed Creative Group Therapy for Processing Trauma and Developing Resilience During Wartime.Journal of personalized medicine · 2026Review
- Neural vulnerability to stress in adolescents: a longitudinal study using polyconnectomic scoring of depression risk.BMC medicine · 2026Article
- Physical exercise and adolescent negative emotions: indirect associations via stress perception and emotional sensitivity.BMC psychology · 2026Article
- Profiles of environmental sensitivity among nursing students on clinical placement and their structural associations with failure mindsets: a latent profile and network analysis.Frontiers in psychology · 2026Article
- The impact of parent-child relationship on adolescent social adjustment following childhood abuse: the moderation of the serotonergic multilocus genetic variation.Frontiers in psychiatry · 2026Article
- Sensory processing sensitivity and overstimulation in daily life: an experience sampling method study.Scientific reports · 2025Article
- Time to incorporate positive experiences and outcomes in psychosis research: genetic differential susceptibility to childhood experiences works for "better and for worse".Translational psychiatry · 2025Article
- Staying Strong Despite Adversity: Resilience in Children and Adolescents.Turkish archives of pediatrics · 2025Article
- Genetic, Epigenetic, and Hormonal Regulation of Stress Phenotypes in Major Depressive Disorder: From Maladaptation to Resilience.Cellular and molecular neurobiology · 2025Review
- Genetic Susceptibility to the Environment Moderates the Impact of Childhood Experiences on Psychotic, Depressive, and Anxiety Dimensions.Schizophrenia bulletin · 2025Article
- Mindfulness meditation as a tool for enhancing recovery and reducing burnout in elite tennis players.Frontiers in psychology · 2025Article
- Environmental and neurodevelopmental contributors to youth mental illness.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024Review
- Advancing differential susceptibility research: Development and validation of the temperamental sensitivity Q-scale.Developmental psychology · 2024Article
- Sex specific gut-microbiota signatures of resilient and comorbid gut-brain phenotypes induced by early life stress.Neurobiology of stress · 2024Article
- Unraveling the complexity of human brain: Structure, function in healthy and disease states.Ageing research reviews · 2024Review
- Serotonin transporter knockout in rats reduces beta- and gamma-band functional connectivity between the orbitofrontal cortex and amygdala during auditory discrimination.Cerebral cortex (New York, N.Y. : 1991) · 2024Article
- An Interpretable Machine Learning Approach to Predict Sensory Processing Sensitivity Trait in Nursing Students.European journal of investigation in health, psychology and education · 2024Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Expert opinion remains divided concerning the impact of putative risk factors on vulnerability to depression and other stress-related disorders. A large body of literature has investigated gene by environment interactions, particularly between the serotonin transporter polymorphism (5-HTTLPR) and negative environments, on the risk for depression. However, fewer studies have simultaneously investigated the outcomes in both negative and positive environments, which could explain some of the inconclusive findings. This is embodied by the concept of differential susceptibility, i.e., the idea that certain common gene polymorphisms, prenatal factors, and traits make some individuals not only disproportionately more susceptible and responsive to negative, vulnerability-promoting environments, but also more sensitive and responsive to positive, resilience-enhancing environmental conditions. Although this concept from the field of developmental psychology is well accepted and supported by behavioral findings, it is striking that its implementation in neuropsychiatric research is limited and that underlying neural mechanisms are virtually unknown. Based on neuroimaging studies that examined how factors mediating differential susceptibility affect brain function, we posit that environmental sensitivity manifests in increased salience network activity, increased salience and default mode network connectivity, and increased salience and central executive network connectivity. These changes in network function may bring about automatic exogenous attention for positive and negative stimuli and flexible attentional set-shifting. We conclude with a call to action; unraveling the neural mechanisms through which differential susceptibility factors mediate vulnerability and resilience may lead us to personalized preventive interventions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.