Observational studyJournal of perinatology : official journal of the California Perinatal Association2021
Positive fluid balance is associated with death and severity of brain injury in neonates with hypoxic-ischemic encephalopathy.
Observational study in Journal of perinatology : official journal of the California Perinatal Association, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
7 citing papers in PubMed, 1 synthesis or guideline pooled it, 13 citations in OpenAlex.
- Neonatal encephalopathy multiorgan scoring systems: systematic review.Frontiers in pediatrics · 2024Pooled it
- Comparison of KDIGO and nRIFLE criteria for acute kidney injury in neonates with hypoxic-ischemic encephalopathy.Pediatric nephrology (Berlin, Germany) · 2026Article
- Cumulative secondary systemic metabolic cerebral insults are associated with disease severity and mortality in neonatal hypoxic-ischaemic encephalopathy: a retrospective study.Frontiers in pediatrics · 2026Article
- Minimal impact of feed intolerance during therapeutic hypothermia for hypoxic ischaemic encephalopathy in a South African cohort with a standardised feeding regimen.Frontiers in pediatrics · 2025Article
- A survey on the diagnosis and management of neonatal hypoxic ischaemic encephalopathy in sub-saharan Africa.Scientific reports · 2024Article
- Comparative evaluation of approach to cardiovascular care in neonatal encephalopathy undergoing therapeutic hypothermia.Journal of perinatology : official journal of the California Perinatal Association · 2022Article
- Creatinine Trends and Patterns in Neonates Undergoing Whole Body Hypothermia: A Systematic Review.Children (Basel, Switzerland) · 2021Review
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Authors and funding
10 authors at 1 institution in 2 countries.
Funding
Abstract
objectiveTo investigate the association between fluid balance during therapeutic hypothermia (TH) and severity of brain injury on magnetic resonance imaging (MRI) in neonates with hypoxic-ischemic encephalopathy (HIE). STUDY
designThis is a secondary analysis of data from a prospective observational study in neonates with HIE. Daily net positive fluid balance during TH was investigated for association with the adverse primary outcome of death or moderate-to-severe brain injury on MRI using multivariable logistic regression.
resultsOf the 150 neonates included, 50 suffered adverse outcome and had significantly higher net positive fluid balance (53 vs. 19 ml/kg/day, p < 0.01) during first 24 hours of TH. Neonates with a net positive fluid balance (>25 ml/kg/day) at 24 hours of TH had 3.4 (95% CI 1.3-9) times higher odds of adverse outcome.
conclusionsPositive fluid balance during TH in neonates with HIE is independently associated with death or moderate-to-severe brain injury on MRI.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.