ArticleScientific reports2021
Retinal microvascular signs and risk of diabetic kidney disease in asian and white populations.
Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 22 citations in OpenAlex.
- Changes of retinal microvascular parameters in patients with type 2 diabetes mellitus with or without diabetic kidney disease.Frontiers in endocrinology · 2026Article
- Association between cerebral lesions and the severity of diabetic cardiovascular disease, retinopathy, and nephropathy-new lessons to learn from neuroimaging.Journal of endocrinological investigation · 2025Review
- Application of a deep-learning marker for morbidity and mortality prediction derived from retinal photographs: a cohort development and validation study.The lancet. Healthy longevity · 2024Article
- Artificial Intelligence-Assisted Perfusion Density as Biomarker for Screening Diabetic Nephropathy.Translational vision science & technology · 2024Article
- Continuous glucose monitoring metrics in pregnancy with type 1 diabetes mellitus.World journal of methodology · 2024Review
- A semantic segmentation method to analyze retinal vascular parameters of diabetic nephropathy.Frontiers in medicine · 2024Article
- Evaluating the potential of retinal photography in chronic kidney disease detection: a review.PeerJ · 2024Review
- Deep learning algorithms to detect diabetic kidney disease from retinal photographs in multiethnic populations with diabetes.Journal of the American Medical Informatics Association : JAMIA · 2023Article
- The LongitudinAl Nationwide stuDy on Management And Real-world outComes of diabetes in India over 3 years (LANDMARC trial).Endocrinology, diabetes & metabolism · 2023Observational
- Diabetic vascular diseases: molecular mechanisms and therapeutic strategies.Signal transduction and targeted therapy · 2023Review
- Identifying myoglobin as a mediator of diabetic kidney disease: a machine learning-based cross-sectional study.Scientific reports · 2022Article
- Status and Trends of the Association Between Diabetic Nephropathy and Diabetic Retinopathy From 2000 to 2021: Bibliometric and Visual Analysis.Frontiers in pharmacology · 2022Article
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Authors and funding
10 authors at 5 institutions in 3 countries.
Funding
Abstract
The objective was to examine prospectively the association between retinal microvascular signs and development of diabetic kidney disease (DKD) in Asian and White populations. We analysed two population-based cohorts, composing of 1,221 Asians (SEED) and 703 White (WESDR) adults with diabetes. Retinal microvascular signs at baseline included vascular caliber (arteriolar-CRAE, and venular-CRVE) and diabetic retinopathy (DR). Incident cases of DKD were identified after ~ 6-year. Incident cases were defined based on eGFR in SEED and proteinuria or history of renal dialysis in WESDR. The incidence of DKD were 11.8% in SEED and 14.0% in WESDR. Wider CRAE in SEED (OR = 1.58 [1.02, 2.45]) and wider CRVE (OR = 1.69 [1.02, 2.80)) in WESDR were associated with increased risk of DKD. Presence of DR was associated with an increased risk of DKD in both cohorts (SEED: OR = 1.91 [1.21, 3.01] in SEED, WESDR: OR = 1.99 [1.18, 3.35]). Adding DR and retinal vascular calibers in the model beyond traditional risk factors led to an improvement of predictive performance of DKD risk between 1.1 and 2.4%; and improved classification (NRI 3 between 9%). Microvascular changes in the retina are longitudinally associated with risk of DKD.
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