ArticleScientific reports2021
Disproportionate left atrial myopathy in heart failure with preserved ejection fraction among participants of the PROMIS-HFpEF study.
Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
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The trial behind it
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Who cites it
41 citing papers in PubMed.
- Atrial Myopathy and Ischemic Stroke in Heart Failure With Preserved Ejection Fraction.The American journal of cardiology · 2023Trial
- Left Atrial Reservoir Strain and Heart Failure Rehospitalization Burden in Acute Heart Failure With Atrial Fibrillation.Echocardiography (Mount Kisco, N.Y.) · 2026Article
- Combined Left Ventricular and Left Atrial Strain Assessment for Long-Term Risk Stratification in Heart Failure With Reduced Ejection Fraction.Echocardiography (Mount Kisco, N.Y.) · 2026Article
- Article
- Demographic and cardiovascular risk factors associated with blood flow characteristics of the left atrium and left atrial appendage.European radiology · 2026Observational
- Review
- Preserved Ejection, Lost Rhythm: A Narrative Review of the Pathophysiology and Management of Heart Failure with Preserved Ejection Fraction and Concomitant Atrial Fibrillation.Journal of clinical medicine · 2026Review
- A simplified approach for diagnosing heart failure with preserved ejection fraction by assessing the left atrium and natriuretic peptides.European journal of heart failure · 2025Article
- Vascular cell adhesion molecule 1: a marker for atrial fibrillation and heart failure risk.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2025Article
- Easing the Strain: Atrial Function After Atrial Shunting.Circulation. Heart failure · 2025Article
- The Prognostic Role of the Left Atrium in Hypertensive Patients with HFpEF: Does Function Matter More than Structure?Life (Basel, Switzerland) · 2025Article
- Prevalence and importance of coronary microvascular dysfunction in patients with heart failure and reduced or mildly reduced ejection fraction.Open heart · 2025Article
- Cardiac Magnetic Resonance Imaging in Heart Failure With Preserved Ejection Fraction.Circulation. Cardiovascular imaging · 2025Review
- Atrial Myopathy and Heart Failure: Immunomolecular Mechanisms and Clinical Implications.International journal of molecular sciences · 2025Review
- Time's imprint on the left atrium: aging and atrial myopathy.The journal of cardiovascular aging · 2025Article
- Investigating Left Atrial Diameter and Heart Failure Onset in Middle-Aged and Elderly: A Retrospective-Prospective Study.Clinical cardiology · 2025Article
- Non-Invasive Hemodynamic Assessment of Heart Failure With Preserved Ejection Fraction.Korean circulation journal · 2025Review
- Left Atrial Strain in Patients with Chronic Heart Failure with Preserved Ejection Fraction: A Narrative Review.Life (Basel, Switzerland) · 2025Review
- Patients with chronic heart failure and predominant left atrial versus left ventricular myopathy.Cardiovascular ultrasound · 2025Observational
- Left Atrial Myopathy in Heart Failure With Preserved Ejection: Don't Raise the Roof!Circulation. Cardiovascular imaging · 2024Article
Corrections and comments
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Authors and funding
17 authors.
Funding
Abstract
Impaired left atrial (LA) function in heart failure with preserved ejection fraction (HFpEF) is associated with adverse outcomes. A subgroup of HFpEF may have LA myopathy out of proportion to left ventricular (LV) dysfunction; therefore, we sought to characterize HFpEF patients with disproportionate LA myopathy. In the prospective, multicenter, Prevalence of Microvascular Dysfunction in HFpEF study, we defined disproportionate LA myopathy based on degree of LA reservoir strain abnormality in relation to LV myopathy (LV global longitudinal strain [GLS]) by calculating the residuals from a linear regression of LA reservoir strain and LV GLS. We evaluated associations of disproportionate LA myopathy with hemodynamics and performed a plasma proteomic analysis to identify proteins associated with disproportionate LA myopathy; proteins were validated in an independent sample. Disproportionate LA myopathy correlated with better LV diastolic function but was associated with lower stroke volume reserve after passive leg raise independent of atrial fibrillation (AF). Additionally, disproportionate LA myopathy was associated with higher pulmonary artery systolic pressure, higher pulmonary vascular resistance, and lower coronary flow reserve. Of 248 proteins, we identified and validated 5 proteins (involved in cardiomyocyte stretch, extracellular matrix remodeling, and inflammation) that were associated with disproportionate LA myopathy independent of AF. In HFpEF, LA myopathy may exist out of proportion to LV myopathy. Disproportionate LA myopathy is a distinct HFpEF subtype associated with worse hemodynamics and a distinct proteomic signature, independent of AF.
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