ArticleScientific reports2021
Cerebral functional networks during sleep in young and older individuals.
Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed, 20 citations in OpenAlex.
- Effects of gender and age on sleep EEG functional connectivity differences in subjects with mild difficulty falling asleep.Frontiers in psychiatry · 2024Article
- Cortical Synchrony and Information Flow during Transition from Wakefulness to Light Non-Rapid Eye Movement Sleep.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- A temporal sequence of thalamic activity unfolds at transitions in behavioral arousal state.Nature communications · 2022Article
- Unveiling whole-brain dynamics in normal aging through Hidden Markov Models.Human brain mapping · 2022Article
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Authors and funding
14 authors at 5 institutions in 2 countries.
Funding
Abstract
Even though sleep modification is a hallmark of the aging process, age-related changes in functional connectivity using functional Magnetic Resonance Imaging (fMRI) during sleep, remain unknown. Here, we combined electroencephalography and fMRI to examine functional connectivity differences between wakefulness and light sleep stages (N1 and N2 stages) in 16 young (23.1 ± 3.3y; 7 women), and 14 older individuals (59.6 ± 5.7y; 8 women). Results revealed extended, distributed (inter-between) and local (intra-within) decreases in network connectivity during sleep both in young and older individuals. However, compared to the young participants, older individuals showed lower decreases in connectivity or even increases in connectivity between thalamus/basal ganglia and several cerebral regions as well as between frontal regions of various networks. These findings reflect a reduced ability of the older brain to disconnect during sleep that may impede optimal disengagement for loss of responsiveness, enhanced lighter and fragmented sleep, and contribute to age effects on sleep-dependent brain plasticity.
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