Evidence map›Paper›PMID 33649357›Full record

ArticleScientific reports2021

Local hyperactivation of L-type Ca

Roman Y Medvedev, Jose L Sanchez-Alonso, Catherine A Mansfield, Aleksandra Judina, Alice J Francis, Christina Pagiatakis, Natalia Trayanova, Alexey V Glukhov, Michele Miragoli, Giuseppe Faggian and 1 more

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
1.9field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 18 citations in OpenAlex.

  1. Downregulation of L-type CaHeart rhythm · 2026
    Article
  2. Article
  3. Article
  4. Article
  5. CaInflammation and regeneration · 2025
    Review
  6. Article
  7. Review
  8. Article
  9. Microtubule-Mediated Regulation of βCirculation research · 2023
    Article
  10. Caveolae-associated cAMP/CaJournal of molecular and cellular cardiology · 2023
    Article
  11. Article
  12. Article
  13. Review
  14. Article
  15. Review
  16. Article
  17. Review
  18. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 6 institutions in 3 countries.

Roman Y MedvedevNational Heart and Lung Institute, Imperial College London, Du Cane Road, London, W12 0NN, UK.
Jose L Sanchez-AlonsoNational Heart and Lung Institute, Imperial College London, Du Cane Road, London, W12 0NN, UK.
Catherine A MansfieldNational Heart and Lung Institute, Imperial College London, Du Cane Road, London, W12 0NN, UK.
Aleksandra JudinaNational Heart and Lung Institute, Imperial College London, Du Cane Road, London, W12 0NN, UK.
Alice J FrancisNational Heart and Lung Institute, Imperial College London, Du Cane Road, London, W12 0NN, UK.
Christina PagiatakisHumanitas Clinical and Research Center - IRCCS, Rozzano, MI, Italy.
Natalia TrayanovaDepartment of Biomedical Engineering and Alliance for Cardiovascular Diagnostic and Treatment Innovation, Johns Hopkins University, Baltimore, USA.
Alexey V GlukhovDepartment of Medicine, Cardiovascular Medicine, Madison School of Medicine and Public Health, University of Wisconsin, Madison, WI, 53705, USA.
Michele MiragoliHumanitas Clinical and Research Center - IRCCS, Rozzano, MI, Italy.
Giuseppe FaggianDipartimento Di Cardiochirurgia, Università Degli Studi Di Verona, Ospedale Borgo Trento, P.le Stefani 1, 37126, Verona, Italy.
Julia GorelikNational Heart and Lung Institute, Imperial College London, Du Cane Road, London, W12 0NN, UK. j.gorelik@imperial.ac.uk.
Imperial College London · GBUniversity of Wisconsin–Madison · USHumanitas University · ITJohns Hopkins Medicine · USProvincia Autonoma di Trento · ITUniversity of Parma · IT

Funding

Infarct-related Ventricular Tachycardia Mechanisms: From Micro to ClinicalR01HL142496 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI TRAYANOVA, NATALIA A. · 2019 to 2022
$3.1M
Exploration of Arrhythmogenic Triggers and Substrates in Heart FailureR01HL126802 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI EFIMOV, IGOR R, GORELIK, JULIA · 2016 to 2019
$2.8M
British Heart Foundation RG/17/13/33173NHLBI NIH HHS R01 HL126802NHLBI NIH HHS R01 HL142496NIH HHS ROI-HL 126802
6 · The paper itself

Abstract

Right ventricle (RV) dysfunction is an independent predictor of patient survival in heart failure (HF). However, the mechanisms of RV progression towards failing are not well understood. We studied cellular mechanisms of RV remodelling in a rat model of left ventricle myocardial infarction (MI)-caused HF. RV myocytes from HF rats show significant cellular hypertrophy accompanied with a disruption of transverse-axial tubular network and surface flattening. Functionally these cells exhibit higher contractility with lower Ca

Indexed as

Calcium SignalingHeart FailureHeart VentriclesMyocytes, CardiacVentricular Dysfunction, RightAnimalsCalciumCalcium Channels, L-TypeMaleRatsCalciumCalcium Channels, L-Type

Identifiers

PMID33649357
PMCPMC7921450
OpenAlexW3135702198

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.