Evidence map›Paper›PMID 33649223›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2021

Progenitor cell diversity in the developing mouse neocortex.

Xiangbin Ruan, Bowei Kang, Cai Qi, Wenhe Lin, Jingshu Wang, Xiaochang Zhang

Open access · greenAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.

0numbers the graph read from it
0cells of the map it votes in
43citing papers in PubMed
4.1field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

43 citing papers in PubMed, 76 citations in OpenAlex.

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  9. Bridging unpaired single-cell multimodal data for integrative analyses with SuperMap.Proceedings of the National Academy of Sciences of the United States of America · 2026
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  15. A conserved logic for the development of cortical layering in tetrapods.bioRxiv : the preprint server for biology · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Xiangbin RuanDepartment of Human Genetics, The University of Chicago, Chicago, IL 60637.ORCID 0000-0002-6895-2070
Bowei KangDepartment of Human Genetics, The University of Chicago, Chicago, IL 60637.
Cai QiDepartment of Human Genetics, The University of Chicago, Chicago, IL 60637.
Wenhe LinDepartment of Human Genetics, The University of Chicago, Chicago, IL 60637.
Jingshu WangDepartment of Statistics, The University of Chicago, Chicago, IL 60637; jingshuw@uchicago.edu xczhang@uchicago.edu.
Xiaochang ZhangDepartment of Human Genetics, The University of Chicago, Chicago, IL 60637; jingshuw@uchicago.edu xczhang@uchicago.edu.ORCID 0000-0001-5768-7470
University of Chicago · US

Funding

Single cell detection of dynamic protein-RNA interactionDP2GM137423 · NIGMS · UNIVERSITY OF CHICAGO · PI ZHANG, XIAOCHANG · 2019 to 2019
$2.4M
Cell Type-specific Alternative Splicing Controls Cerebral Cortical DevelopmentK01MH109747 · NIMH · UNIVERSITY OF CHICAGO · PI ZHANG, XIAOCHANG · 2016 to 2019
$581k
NIGMS NIH HHS DP2 GM137423NIMH NIH HHS K01 MH109747
6 · The paper itself

Abstract

In the mammalian neocortex, projection neuron types are sequentially generated by the same pool of neural progenitors. How neuron type specification is related to developmental timing remains unclear. To determine whether temporal gene expression in neural progenitors correlates with neuron type specification, we performed single-cell RNA sequencing (scRNA-Seq) analysis of the developing mouse neocortex. We uncovered neuroepithelial cell enriched genes such as

Indexed as

Cell DifferentiationAnimalsBasic Helix-Loop-Helix ProteinsHMGA2 ProteinMiceNeocortexNerve Tissue ProteinsNeural Stem CellsNeurogliaPOU Domain FactorsRepressor ProteinsT-Box Domain ProteinsBasic Helix-Loop-Helix ProteinsEomes protein, mouseHes5 protein, mouseHMGA2 ProteinNerve Tissue ProteinsPou3f2 protein, mousePOU Domain FactorsRepressor ProteinsT-Box Domain Proteinscell identitydevelopmental timingneural progenitorneuronal diversityscRNA-Seq

Identifiers

PMID33649223
PMCPMC7958455
OpenAlexW3135143003

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.