ArticleProceedings of the National Academy of Sciences of the United States of America2021
Nonthermal and reversible control of neuronal signaling and behavior by midinfrared stimulation.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 68 papers.
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Who cites it
68 citing papers in PubMed.
- Non-invasive and painless mid-infrared modulation increases collagen in human and mouse skin.Journal of advanced research · 2026Article
- Thermophoresis induced by photothermal shock alters reversal potential and capacitance in neurons.Biophysical journal · 2026Article
- AlGaAs-on-insulator microresonators satisfying broadband phase matching for longwave infrared spectral upconversion.Nanoscale advances · 2026Article
- Terahertz wave stimulation improves visual recognition memory via the activation of excitatory neurons in the perirhinal cortex.Cell communication and signaling : CCS · 2026Article
- Mid-Infrared Light Exhibits Tissue-Specific Transmittance and Modulates Neural Signal Conduction Along Axons.Neuroscience bulletin · 2026Article
- Prelimbic cortex layer 5 GABAergic neurons mediate chronic pain and memory impairment by regulating excitatory/inhibitory imbalance.The journal of headache and pain · 2026Article
- Enhancement of Calcium Ion Permeation via Resonant Coupling of Ion and Terahertz Waves in Voltage Gated Calcium Channels.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Terahertz Photons Promote Corneal Injury Repair via Epithelial Proliferation, Migration, and Inflammation Reduction.Investigative ophthalmology & visual science · 2026Article
- Triggering action potentials of a single neuron by multiphoton excitation elicits visually guided behavior.Nature communications · 2026Article
- Computational Study of Terahertz-Induced Phase Transitions at Molecular Interfaces.Research (Washington, D.C.) · 2026Article
- Terahertz Modulation of Biomolecular Dynamics: Physical Mechanisms, Biological Implications, and Future Challenges.Research (Washington, D.C.) · 2026Review
- Mid-infrared photons relieve tinnitus-like behavior of mice by regulating HCN2 ion channels in the medial geniculate body.Annals of medicine · 2025Article
- Focal thalamic infrared neural stimulation propagates dynamical transformations in auditory cortex.Journal of neural engineering · 2025Article
- Protocol for simulating the effect of THz electromagnetic field on ion channels.Quantitative biology (Beijing, China) · 2025Article
- Terahertz's silent revolution in physics, engineering, and life science: Beyond the spectrum.Fundamental research · 2025Review
- Single-Molecule Vibrational Thermometry.The journal of physical chemistry. B · 2025Article
- Computational study of terahertz-driven controllable molecular isomerization.Nature communications · 2025Article
- Neurons derived from NeuroD1-expressing astrocytes transition through transit-amplifying intermediates but lack functional maturity.Science advances · 2025Article
- Spatiotemporal terahertz modulation enhances NMDAR-mediated miniature EPSCs.Scientific reports · 2025Article
- How spatial temperature gradients modulate infrared stimulation of the ex vivo rat sciatic nerve.Biophysical journal · 2025Article
8 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
13 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Various neuromodulation approaches have been employed to alter neuronal spiking activity and thus regulate brain functions and alleviate neurological disorders. Infrared neural stimulation (INS) could be a potential approach for neuromodulation because it requires no tissue contact and possesses a high spatial resolution. However, the risk of overheating and an unclear mechanism hamper its application. Here we show that midinfrared stimulation (MIRS) with a specific wavelength exerts nonthermal, long-distance, and reversible modulatory effects on ion channel activity, neuronal signaling, and sensorimotor behavior. Patch-clamp recording from mouse neocortical pyramidal cells revealed that MIRS readily provides gain control over spiking activities, inhibiting spiking responses to weak inputs but enhancing those to strong inputs. MIRS also shortens action potential (AP) waveforms by accelerating its repolarization, through an increase in voltage-gated K
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.